Ccnb1ip1 cyclin B1 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnb1ip1provided by MGI
Official Full Name: cyclin B1 interacting protein 1provided by MGI
Primary source: MGI:MGI:2685134
See related: Ensembl:ENSMUSG00000071470 AllianceGenome:MGI:2685134
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mei4; Gm288; Hei10
Summary: Predicted to enable identical protein binding activity. Involved in chiasma assembly. Acts upstream of or within blastocyst formation and spermatid development. Located in condensed nuclear chromosome. Colocalizes with synaptonemal complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human CCNB1IP1 (cyclin B1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 2.9) See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 26.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51026706..51033185, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (50789249..50795728, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that the (GGA)14 region that forms the T:H:H:T dimerized G4 structure functions as a negative regulator of the Ccnb1ip1 enhancer
Title: G-quadruplex-forming GGA repeat region functions as a negative regulator of the Ccnb1ip1 enhancer.
Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombination.
Title: A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Mei4 and Rec114, are evolutionarily conserved in most eukaryotes and Mei4(-/-) mice are deficient in meiotic DSB formation, thus showing the functional conservation of Mei4 in mice
Title: Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.
Cloning and characterization of the mei4 ortholog of Hei10 (also known as Gm288 in mouse) demonstrates a novel link between cell cycle regulation and mismatch repair during prophase I.
Title: Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ccnb1ip1 (e-PCR), detects polymorphism
- UniSTS:507408

Ccnb1ip1 (e-PCR), detects polymorphism
- UniSTS:507409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	TAS Traceable Author Statement more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CCNB1IP1

Names: RING-type E3 ubiquitin transferase CCNB1IP1

NP_001104589.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111119.1 → NP_001104589.1 E3 ubiquitin-protein ligase CCNB1IP1

Status: PROVISIONAL

Source sequence(s)

AC027184

Consensus CDS

CCDS49477.1

UniProtKB/Swiss-Prot

D3Z3K2

Related

ENSMUSP00000093622.4, ENSMUST00000095932.5

Conserved Domains (2) summary

pfam13851
Location:115 → 163

GAS; Growth-arrest specific micro-tubule binding

pfam14634
Location:10 → 52

zf-RING_5; zinc-RING finger domain