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    Pla2g1b phospholipase A2, group IB, pancreas [ Mus musculus (house mouse) ]

    Gene ID: 18778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pla2g1bprovided by MGI
    Official Full Name
    phospholipase A2, group IB, pancreasprovided by MGI
    Primary source
    MGI:MGI:101842
    See related
    Ensembl:ENSMUSG00000029522 AllianceGenome:MGI:101842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pla2a; sPLA2IB
    Summary
    Enables phospholipase A2 activity and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; glycerophospholipid metabolic process; and positive regulation of podocyte apoptotic process. Predicted to act upstream of or within phospholipid catabolic process. Located in extracellular region. Is expressed in liver; lung; and spleen. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 11970.9) See more
    Orthologs
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    Genomic context

    See Pla2g1b in Genome Data Viewer
    Location:
    5 F; 5 56.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115604201..115612781)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115466142..115474722)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13832 Neighboring gene RIKEN cDNA A930005G22 gene Neighboring gene musashi RNA-binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14129 Neighboring gene sirtuin 4 Neighboring gene predicted gene, 42007 Neighboring gene predicted gene, 24265

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC6679

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylglycerol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phospholipid catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase A2
    Names
    PLA2-Ib
    group IB phospholipase A2
    phosphatidylcholine 2-acylhydrolase 1B
    NP_001343515.1
    NP_001343516.1
    NP_035237.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356586.1NP_001343515.1  phospholipase A2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC117735, BY088109
      UniProtKB/TrEMBL
      D3YWH2
      Related
      ENSMUSP00000120743.2, ENSMUST00000125568.2
      Conserved Domains (1) summary
      smart00085
      Location:23145
      PA2c; Phospholipase A2
    2. NM_001356587.1NP_001343516.1  phospholipase A2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117735, AK019009
      Consensus CDS
      CCDS89977.1
      UniProtKB/TrEMBL
      D3Z1N8
      Related
      ENSMUSP00000107702.2, ENSMUST00000112071.8
      Conserved Domains (1) summary
      cl05417
      Location:2465
      PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    3. NM_011107.2NP_035237.1  phospholipase A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035237.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC117735, AK008668
      Consensus CDS
      CCDS19592.1
      UniProtKB/Swiss-Prot
      A6H6K5, Q9D7E2, Q9D884, Q9Z0Y2
      UniProtKB/TrEMBL
      D3YWH2
      Related
      ENSMUSP00000031495.5, ENSMUST00000031495.11
      Conserved Domains (1) summary
      smart00085
      Location:24146
      PA2c; Phospholipase A2

    RNA

    1. NR_151517.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC117735

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115604201..115612781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)