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    Psmb4 proteasome (prosome, macropain) subunit, beta type 4 [ Mus musculus (house mouse) ]

    Gene ID: 19172, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb4provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type 4provided by MGI
    Primary source
    MGI:MGI:1098257
    See related
    Ensembl:ENSMUSG00000005779 AllianceGenome:MGI:1098257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pros-27
    Summary
    Enables lipopolysaccharide binding activity. Involved in negative regulation of inflammatory response to antigenic stimulus. Part of proteasome core complex. Is expressed in cerebral cortex and embryo. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 131.5), large intestine adult (RPKM 127.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Psmb4 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94791635..94794269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94884324..94886958, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08357 Neighboring gene predicted gene, 40094 Neighboring gene pogo transposable element with ZNF domain Neighboring gene STARR-positive B cell enhancer mm9_chr3:94641125-94641426 Neighboring gene special AT-rich sequence binding protein 1 pseudogene Neighboring gene predicted gene, 36237 Neighboring gene predicted gene, 26279 Neighboring gene selenium binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit beta type-4
    Names
    beta-7
    low molecular mass protein 3
    macropain beta chain
    multicatalytic endopeptidase complex beta chain
    proteasome beta chain
    proteasome chain 3
    proteasome subunit beta-7
    NP_032971.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008945.3NP_032971.2  proteasome subunit beta type-4

      See identical proteins and their annotated locations for NP_032971.2

      Status: VALIDATED

      Source sequence(s)
      AK077448, CB058553
      Consensus CDS
      CCDS17597.1
      UniProtKB/Swiss-Prot
      P99026, Q3THC0, Q3THI3, Q3U0S0, Q3UVQ4, Q62008, Q8BK27, Q91VV7
      Related
      ENSMUSP00000005923.7, ENSMUST00000005923.7
      Conserved Domains (2) summary
      COG0638
      Location:45241
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03760
      Location:52247
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94791635..94794269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)