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    Tifab TRAF-interacting protein with forkhead-associated domain, family member B [ Mus musculus (house mouse) ]

    Gene ID: 212937, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tifabprovided by MGI
    Official Full Name
    TRAF-interacting protein with forkhead-associated domain, family member Bprovided by MGI
    Primary source
    MGI:MGI:2385852
    See related
    Ensembl:ENSMUSG00000049625 AllianceGenome:MGI:2385852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables deubiquitinase activator activity. Acts upstream of with a negative effect on toll-like receptor signaling pathway. Acts upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 9.0), lung adult (RPKM 4.1) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tifab in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56318917..56326816, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56173703..56179002, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene macroH2A.1 histone Neighboring gene STARR-seq mESC enhancer starr_34633 Neighboring gene predicted gene, 31485 Neighboring gene STARR-seq mESC enhancer starr_34635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:56277360-56277561 Neighboring gene predicted gene, 31657 Neighboring gene predicted gene, 25148 Neighboring gene STARR-seq mESC enhancer starr_34636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:56298990-56299177 Neighboring gene neurogenin 1 downstream neighbor lncRNA Neighboring gene neurogenin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC32345, MGC37193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deubiquitinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in auditory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in auditory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cochlea development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in craniofacial suture morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in craniofacial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in genitalia morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hard palate morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hard palate morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learned vocalization behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learned vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mastication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mastication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of relaxation of muscle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of relaxation of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of saliva secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peristalsis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of muscle organ development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thorax and anterior abdomen determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thorax and anterior abdomen determination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_negative_effect toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in trigeminal nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trigeminal nerve development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vestibulocochlear nerve formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vestibulocochlear nerve formation ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TRAF-interacting protein with FHA domain-containing protein B
    Names
    TIFA like protein
    TIFA related protein TIFAB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168615.1NP_001162086.1  TRAF-interacting protein with FHA domain-containing protein B

      See identical proteins and their annotated locations for NP_001162086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124395, AK153654, BY209244
      Consensus CDS
      CCDS26558.1
      UniProtKB/Swiss-Prot
      Q05DP7, Q571I3, Q8JZM6
      Related
      ENSMUSP00000152976.2, ENSMUST00000225063.2
      Conserved Domains (1) summary
      pfam00498
      Location:37107
      FHA; FHA domain
    2. NM_145976.4NP_666088.1  TRAF-interacting protein with FHA domain-containing protein B

      See identical proteins and their annotated locations for NP_666088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124395, AK036643, BY209244
      Consensus CDS
      CCDS26558.1
      UniProtKB/Swiss-Prot
      Q05DP7, Q571I3, Q8JZM6
      Related
      ENSMUSP00000131162.2, ENSMUST00000169652.3
      Conserved Domains (1) summary
      pfam00498
      Location:37107
      FHA; FHA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      56318917..56326816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517204.5XP_006517267.1  TRAF-interacting protein with FHA domain-containing protein B isoform X1

      See identical proteins and their annotated locations for XP_006517267.1

      UniProtKB/Swiss-Prot
      Q05DP7, Q571I3, Q8JZM6
      Conserved Domains (1) summary
      pfam00498
      Location:37107
      FHA; FHA domain