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    Ric3 RIC3 acetylcholine receptor chaperone [ Mus musculus (house mouse) ]

    Gene ID: 320360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ric3provided by MGI
    Official Full Name
    RIC3 acetylcholine receptor chaperoneprovided by MGI
    Primary source
    MGI:MGI:2443887
    See related
    Ensembl:ENSMUSG00000048330 AllianceGenome:MGI:2443887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130307J04Rik
    Summary
    Enables protein folding chaperone. Acts upstream of or within protein-containing complex assembly. Located in endoplasmic reticulum and membrane. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 12.0), cortex adult (RPKM 7.6) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ric3 in Genome Data Viewer
    Location:
    7 E3; 7 57.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108633475..108682538, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109034268..109083432, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39067 Neighboring gene predicted gene, 32309 Neighboring gene TUB bipartite transcription factor Neighboring gene predicted gene, 25450 Neighboring gene STARR-seq mESC enhancer starr_19793 Neighboring gene predicted gene 44781 Neighboring gene LIM domain only 1 Neighboring gene STARR-seq mESC enhancer starr_19794 Neighboring gene predicted gene, 32563

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein RIC-3
    Names
    resistance to inhibitors of cholinesterase 3 homolog
    resistant to inhibitor of cholinesterase 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038624.1NP_001033713.1  protein RIC-3 isoform a precursor

      See identical proteins and their annotated locations for NP_001033713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform a).
      Source sequence(s)
      BC059258, BY241896, BY279630
      Consensus CDS
      CCDS21733.1
      UniProtKB/Swiss-Prot
      Q6PCM7, Q8BPM6, Q8C4G2
      Related
      ENSMUSP00000056990.7, ENSMUST00000055993.13
      Conserved Domains (1) summary
      pfam15361
      Location:19164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3
    2. NM_001311161.1NP_001298090.1  protein RIC-3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter compared to isoform a.
      Source sequence(s)
      AK138641, BC059258, BY241896
      Consensus CDS
      CCDS80778.1
      UniProtKB/TrEMBL
      D3YTZ9
      Related
      ENSMUSP00000112788.2, ENSMUST00000120876.2
      Conserved Domains (1) summary
      pfam15361
      Location:19164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3
    3. NM_178780.3NP_848895.2  protein RIC-3 isoform b precursor

      See identical proteins and their annotated locations for NP_848895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1 that leads to a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK149334, BY279630
      UniProtKB/Swiss-Prot
      Q8BPM6
      Conserved Domains (1) summary
      pfam15361
      Location:19164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      108633475..108682538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507942.3XP_006508005.1  protein RIC-3 isoform X1

      See identical proteins and their annotated locations for XP_006508005.1

      UniProtKB/Swiss-Prot
      Q8BPM6
    2. XM_006507943.5XP_006508006.1  protein RIC-3 isoform X1

      See identical proteins and their annotated locations for XP_006508006.1

      UniProtKB/Swiss-Prot
      Q8BPM6