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    Stk3 serine/threonine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56274, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stk3provided by MGI
    Official Full Name
    serine/threonine kinase 3provided by MGI
    Primary source
    MGI:MGI:1928487
    See related
    Ensembl:ENSMUSG00000022329 AllianceGenome:MGI:1928487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MST; Mst2; Mst3; Ste20; mess1; 0610042I06Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and transcription regulator activator activity. Involved in hippo signaling. Acts upstream of or within several processes, including chordate embryonic development; hepatocyte apoptotic process; and regulation of signal transduction. Located in cytoplasm. Is expressed in female associated reproductive structure; lung; male associated reproductive structure; and renal vasculature. Orthologous to human STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 3.7), liver E14 (RPKM 3.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stk3 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.34 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34875645..35155990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34875499..35155882, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875 Neighboring gene STARR-seq mESC enhancer starr_38332 Neighboring gene STARR-seq mESC enhancer starr_38333 Neighboring gene STARR-seq mESC enhancer starr_38334 Neighboring gene STARR-seq mESC enhancer starr_38335 Neighboring gene K+ voltage-gated channel, subfamily S, 2 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497 Neighboring gene STARR-seq mESC enhancer starr_38340 Neighboring gene odd-skipped related 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription regulator activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation involved in embryonic placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocardium development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neural tube formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within primitive hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell differentiation involved in embryonic placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase 3
    Names
    MST-2
    STE20-like kinase MST2
    mammalian STE20-like protein kinase 2
    protein kinase homolog
    NP_001344750.1
    NP_062609.2
    XP_006520182.1
    XP_030104530.1
    XP_030104531.1
    XP_036015421.1
    XP_036015422.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357821.1NP_001344750.1  serine/threonine-protein kinase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116950, AC122907
      UniProtKB/TrEMBL
      A0A2I3BQE0
      Conserved Domains (2) summary
      cd06612
      Location:1205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:370417
      Mst1_SARAH; C terminal SARAH domain of Mst1
    2. NM_019635.2NP_062609.2  serine/threonine-protein kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_062609.2

      Status: VALIDATED

      Source sequence(s)
      AY058922, BC049123, BY783841, U28726
      Consensus CDS
      CCDS37059.1
      UniProtKB/Swiss-Prot
      Q60877, Q80UG4, Q8CI58, Q9JI10
      UniProtKB/TrEMBL
      A0A2I3BQE0
      Related
      ENSMUSP00000018476.8, ENSMUST00000018476.14
      Conserved Domains (2) summary
      cd06612
      Location:23278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:443490
      Mst1_SARAH; C terminal SARAH domain of Mst1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34875645..35155990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248670.2XP_030104530.1  serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BQE0
      Related
      ENSMUSP00000064225.8, ENSMUST00000067033.8
      Conserved Domains (2) summary
      pfam11629
      Location:345392
      Mst1_SARAH; C terminal SARAH domain of Mst1
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036159528.1XP_036015421.1  serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BQE0
      Conserved Domains (2) summary
      pfam11629
      Location:345392
      Mst1_SARAH; C terminal SARAH domain of Mst1
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030248671.2XP_030104531.1  serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      Q9CW82
      Conserved Domains (2) summary
      pfam11629
      Location:304351
      Mst1_SARAH; C terminal SARAH domain of Mst1
      cl21453
      Location:1139
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036159529.1XP_036015422.1  serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      Q9CW82
      Conserved Domains (2) summary
      pfam11629
      Location:304351
      Mst1_SARAH; C terminal SARAH domain of Mst1
      cl21453
      Location:1139
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006520119.5XP_006520182.1  serine/threonine-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BQE0
      Conserved Domains (1) summary
      cd06612
      Location:23278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2