Cxcr3 C-X-C motif chemokine receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcr3provided by MGI
Official Full Name: C-X-C motif chemokine receptor 3provided by MGI
Primary source: MGI:MGI:1277207
See related: Ensembl:ENSMUSG00000050232 AllianceGenome:MGI:1277207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd183; Cmkar3
Summary: This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]
Expression: Biased expression in spleen adult (RPKM 18.9), mammary gland adult (RPKM 10.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 44.58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (100775141..100777753, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (101731535..101734147, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells.
Title: Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells.
CXCR3 participates in asymmetric division of mouse oocytes by modulating actin dynamics.
Title: CXCR3 participates in asymmetric division of mouse oocytes by modulating actin dynamics.
CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-beta1/Smad2/3 signaling in mouse viral myocarditis.
Title: CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-β1/Smad2/3 signaling in mouse viral myocarditis.
Homocysteine modulates CXCL10/CXCR3 axis activity to induce endothelial dysfunction.
Title: Homocysteine modulates CXCL10/CXCR3 axis activity to induce endothelial dysfunction.
Detrimental Role of CXCR3 in alpha-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury.
Title: Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury.
The chemokine receptor CXCR3 promotes CD8[+] T cell-dependent lung pathology during influenza pathogenesis.
Title: The chemokine receptor CXCR3 promotes CD8(+) T cell-dependent lung pathology during influenza pathogenesis.
Platelet factors attenuate inflammation and rescue cognition in ageing.
Title: Platelet factors attenuate inflammation and rescue cognition in ageing.
IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines.
Title: IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines.
CXCR3 deficiency decreases autoantibody production by inhibiting aberrant activated T follicular helper cells and B cells in lupus mice.
Title: CXCR3 deficiency decreases autoantibody production by inhibiting aberrant activated T follicular helper cells and B cells in lupus mice.
CXCR3 Inhibition Blocks the NF-kappaB Signaling Pathway by Elevating Autophagy to Ameliorate Lipopolysaccharide-Induced Intestinal Dysfunction in Mice.
Title: CXCR3 Inhibition Blocks the NF-κB Signaling Pathway by Elevating Autophagy to Ameliorate Lipopolysaccharide-Induced Intestinal Dysfunction in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (197)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (7) 1 citation

General gene information

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Markers

AB003174 (e-PCR)
- UniSTS:186179

Cxcr3 (e-PCR), detects polymorphism
- UniSTS:495984

PMC127682P1 (e-PCR)
- UniSTS:270557

RH142674 (e-PCR)
- UniSTS:231921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X-C chemokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables C-X-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables chemokine binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 3

Names: IP-10 receptor; chemokine (C-X-C motif) receptor 3; interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009910.3 → NP_034040.1 C-X-C chemokine receptor type 3

See identical proteins and their annotated locations for NP_034040.1

Status: REVIEWED

Source sequence(s)

AL805980

Consensus CDS

CCDS30319.1

UniProtKB/Swiss-Prot

O88410, Q4V9Y6, Q9QWN6

Related

ENSMUSP00000052444.7, ENSMUST00000056614.7

Conserved Domains (2) summary

pfam00001
Location:73 → 317

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam04145
Location:168 → 242

Ctr; Ctr copper transporter family