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    Pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) [ Mus musculus (house mouse) ]

    Gene ID: 59001, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pole3provided by MGI
    Official Full Name
    polymerase (DNA directed), epsilon 3 (p17 subunit)provided by MGI
    Primary source
    MGI:MGI:1933378
    See related
    Ensembl:ENSMUSG00000028394 AllianceGenome:MGI:1933378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    YBL1; 1810034K18Rik
    Summary
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; leading strand elongation; and regulation of nucleobase-containing compound metabolic process. Located in pericentric heterochromatin. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and sensory organ. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 65.6), liver E14 (RPKM 42.8) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Pole3 in Genome Data Viewer
    Location:
    4 B3; 4 33.17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62440889..62443305, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62523798..62525014, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3 Neighboring gene RIKEN cDNA 4933430I17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62186055-62186242 Neighboring gene aminolevulinate, delta-, dehydratase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62213110-62213293 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62222257-62222558 Neighboring gene regulator of G-protein signaling 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62322547-62322847 Neighboring gene STARR-seq mESC enhancer starr_10430 Neighboring gene predicted gene, 52741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CHRAC NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of epsilon DNA polymerase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase epsilon subunit 3
    Names
    DNA polymerase II subunit 3
    DNA polymerase epsilon subunit p17
    NF-YB-like protein
    YB-like protein 1
    NP_067473.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021498.3NP_067473.2  DNA polymerase epsilon subunit 3

      See identical proteins and their annotated locations for NP_067473.2

      Status: VALIDATED

      Source sequence(s)
      AL732594
      Consensus CDS
      CCDS18244.1
      UniProtKB/TrEMBL
      A0A0R4J091
      Related
      ENSMUSP00000030091.4, ENSMUST00000030091.10
      Conserved Domains (1) summary
      cl23735
      Location:1105
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62440889..62443305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)