Ccnl2 cyclin L2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnl2provided by MGI
Official Full Name: cyclin L2provided by MGI
Primary source: MGI:MGI:1927119
See related: Ensembl:ENSMUSG00000029068 AllianceGenome:MGI:1927119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcee; SB138; Ania-6b; HCLA-150; 1700010A01Rik; 1810019L15Rik; 2010319M22Rik
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CCNL2 (cyclin L2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 65.5), bladder adult (RPKM 45.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.47 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155894468..155909005)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155810219..155824543)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that overexpression of CCNL2 inhibited proliferation and differentiation of mouse embryonic carcinoma P19 cells and induced them to undergo apoptosis, possibly through the Wnt signal transduction pathway.
Title: Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI428898 (e-PCR)
- UniSTS:165379

U37351 (e-PCR)
- UniSTS:125739

RH125899 (e-PCR)
- UniSTS:162623

Ccnl2 (e-PCR), detects polymorphism
- UniSTS:506786

AW261738 (e-PCR)
- UniSTS:179121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of centrosome cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-L2

Names: cyclin Ania-6b; paneth cell enhanced expression; paneth cell-enhanced expression protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401306.1 → NP_001388235.1 cyclin-L2 isoform 2

Status: VALIDATED

Source sequence(s)

AL670236
NM_207678.3 → NP_997561.1 cyclin-L2 isoform 1

See identical proteins and their annotated locations for NP_997561.1

Status: VALIDATED

Source sequence(s)

AL670236

Consensus CDS

CCDS19042.1

UniProtKB/Swiss-Prot

A2AD95, A2RSY2, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9JJA7, Q9QXH5

Related

ENSMUSP00000030944.5, ENSMUST00000030944.11

Conserved Domains (2) summary

smart00385
Location:198 → 280

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

cd00043
Location:75 → 151

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155894468..155909005

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164254.1 → XP_036020147.1 cyclin-L2 isoform X1

Conserved Domains (2) summary

cd20590
Location:33 → 188

CYCLIN_CCNL2_rpt1; first cyclin box found in cyclin-2 (CCNL2) and similar proteins

cd20593
Location:193 → 315

CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins
XM_011250305.4 → XP_011248607.2 cyclin-L2 isoform X2

Conserved Domains (1) summary

cl40454
Location:1 → 95

CYCLIN_SF; Cyclin box fold superfamily
XM_036164256.1 → XP_036020149.1 cyclin-L2 isoform X3

Conserved Domains (1) summary

cl40454
Location:1 → 95

CYCLIN_SF; Cyclin box fold superfamily
XM_036164255.1 → XP_036020148.1 cyclin-L2 isoform X2

Conserved Domains (1) summary

cl40454
Location:1 → 95

CYCLIN_SF; Cyclin box fold superfamily
XM_030253679.2 → XP_030109539.1 cyclin-L2 isoform X3

Conserved Domains (1) summary

cl40454
Location:1 → 95

CYCLIN_SF; Cyclin box fold superfamily

RNA

XR_881434.4 RNA Sequence
XR_001784166.3 RNA Sequence
XR_001784165.3 RNA Sequence
XR_003954988.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_018856.2: Suppressed sequence

Description

NM_018856.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.