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    Deptor DEP domain containing MTOR-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 97998, updated on 9-Dec-2024

    Summary

    Official Symbol
    Deptorprovided by MGI
    Official Full Name
    DEP domain containing MTOR-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2146322
    See related
    Ensembl:ENSMUSG00000022419 AllianceGenome:MGI:2146322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Depdc6
    Summary
    Predicted to enable phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Predicted to be active in lysosomal membrane. Is expressed in brain and lung. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 11.6), subcutaneous fat pad adult (RPKM 8.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Deptor in Genome Data Viewer
    Location:
    15 D1; 15 21.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54975824..55122667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55112317..55259273)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene predicted gene, 26296 Neighboring gene predicted gene, 35312

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4200

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC2 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DEP domain-containing mTOR-interacting protein
    Names
    DEP domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037937.4NP_001033026.1  DEP domain-containing mTOR-interacting protein isoform b

      See identical proteins and their annotated locations for NP_001033026.1

      Status: VALIDATED

      Source sequence(s)
      AC124659
      Consensus CDS
      CCDS27475.1
      UniProtKB/TrEMBL
      B2ZRS7, B2ZRS8
      Related
      ENSMUSP00000023056.8, ENSMUST00000023056.8
      Conserved Domains (3) summary
      cd00992
      Location:327391
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:121205
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cl02442
      Location:29105
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    2. NM_145470.4NP_663445.2  DEP domain-containing mTOR-interacting protein isoform a

      See identical proteins and their annotated locations for NP_663445.2

      Status: VALIDATED

      Source sequence(s)
      AC124659
      Consensus CDS
      CCDS27474.1
      UniProtKB/Swiss-Prot
      Q3UM00, Q3UT08, Q570Y9
      UniProtKB/TrEMBL
      B2ZRS3, B2ZRS8
      Related
      ENSMUSP00000094167.4, ENSMUST00000096433.10
      Conserved Domains (3) summary
      cd00992
      Location:339403
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:133217
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:36117
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      54975824..55122667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)