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    Map7 microtubule-associated protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293016, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map7provided by RGD
    Official Full Name
    microtubule-associated protein 7provided by RGD
    Primary source
    RGD:1308866
    See related
    EnsemblRapid:ENSRNOG00000012701 AllianceGenome:RGD:1308866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mtap7
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization and protein localization to plasma membrane. Predicted to act upstream of or within several processes, including glycosphingolipid metabolic process; male gonad development; and response to retinoic acid. Located in axon. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 198.7), Brain (RPKM 95.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map7 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16730000..16857173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (14910433..15037574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15620665..15748203)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene uncharacterized LOC102547350 Neighboring gene uncharacterized LOC120098800 Neighboring gene uncharacterized LOC120098801 Neighboring gene U6 spliceosomal RNA Neighboring gene BCL2-associated transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. Tymanskyj SR, et al. Elife, 2018 Aug 22. PMID 30132755, Free PMC Article
    2. MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons. Tymanskyj SR, et al. J Neurosci, 2017 Feb 8. PMID 28069923, Free PMC Article
    3. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Komada M, et al. Genes Dev, 2000 Jun 1. PMID 10837026, Free PMC Article
    4. Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). Suzuki M, et al. J Biol Chem, 2003 Dec 19. PMID 14517216
    5. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. Rabionet M, et al. J Biol Chem, 2008 May 9. PMID 18308723, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle transport behaviors, particularly pause/speed switching.
      Title: MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport.
    2. MAP7 promotes axon collateral branch morphogenesis and neural circuit function in dorsal root ganglion neurons.
      Title: MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Leydig cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Sertoli cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ensconsin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106270.2 → NP_001099740.2  ensconsin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GKH8
      Related
      ENSRNOP00000099528.1, ENSRNOT00000126107.1
      Conserved Domains (1) summary
      pfam05672
      Location:471 → 623
      MAP7; MAP7 (E-MAP-115) family

    2. NM_001198638.2 → NP_001185567.1  ensconsin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and lacks in-frame two consecutive exons in the CDS, as comapared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AJJ5
      Related
      ENSRNOP00000098641.1, ENSRNOT00000139018.1
      Conserved Domains (1) summary
      pfam05672
      Location:368 → 520
      MAP7; MAP7 (E-MAP-115) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16730000..16857173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105408.2 → XP_038961336.1  ensconsin isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJJ5, F1MA82
      Related
      ENSRNOP00000017401.6, ENSRNOT00000017401.7
      Conserved Domains (2) summary
      pfam05672
      Location:451 → 603
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:89 → 146
      Radial_spoke_3; Radial spoke protein 3

    2. XM_063284418.1 → XP_063140488.1  ensconsin isoform X10

      Related
      ENSRNOP00000093262.2, ENSRNOT00000094977.2

    3. XM_039105409.2 → XP_038961337.1  ensconsin isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJJ5
      Related
      ENSRNOP00000079962.2, ENSRNOT00000096725.2
      Conserved Domains (2) summary
      pfam05672
      Location:443 → 595
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:89 → 146
      Radial_spoke_3; Radial spoke protein 3

    4. XM_063284425.1 → XP_063140495.1  ensconsin isoform X12

    5. XM_039105391.2 → XP_038961319.1  ensconsin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKH8
      Conserved Domains (2) summary
      pfam05672
      Location:473 → 625
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:111 → 168
      Radial_spoke_3; Radial spoke protein 3

    6. XM_063284427.1 → XP_063140497.1  ensconsin isoform X12

    7. XM_063284432.1 → XP_063140502.1  ensconsin isoform X13

    8. XM_039105431.2 → XP_038961359.1  ensconsin isoform X6

      UniProtKB/TrEMBL
      A0A8I6AJJ5
      Conserved Domains (2) summary
      pfam05672
      Location:431 → 583
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:69 → 126
      Radial_spoke_3; Radial spoke protein 3

    9. XM_063284408.1 → XP_063140478.1  ensconsin isoform X7

      UniProtKB/TrEMBL
      A0A8I6AJA9
      Related
      ENSRNOP00000075655.3, ENSRNOT00000079845.3

    10. XM_039105407.2 → XP_038961335.1  ensconsin isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJJ5
      Conserved Domains (2) summary
      pfam05672
      Location:460 → 612
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:98 → 155
      Radial_spoke_3; Radial spoke protein 3

    11. XM_063284402.1 → XP_063140472.1  ensconsin isoform X3

      UniProtKB/TrEMBL
      A0A0G2KB52
      Related
      ENSRNOP00000093069.2, ENSRNOT00000098943.2

    12. XM_063284410.1 → XP_063140480.1  ensconsin isoform X8

    13. XM_063284414.1 → XP_063140484.1  ensconsin isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZPN4

    14. XM_063284422.1 → XP_063140492.1  ensconsin isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version

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