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    Ric3 RIC3 acetylcholine receptor chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687147, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ric3provided by RGD
    Official Full Name
    RIC3 acetylcholine receptor chaperoneprovided by RGD
    Primary source
    RGD:1588939
    See related
    EnsemblRapid:ENSRNOG00000014691 AllianceGenome:RGD:1588939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables acetylcholine receptor binding activity. Acts upstream of or within cholinergic synaptic transmission and positive regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 169.3), Adrenal (RPKM 53.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ric3 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172465638..172521349, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163030621..163086583, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (173629218..173682226, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 10 Neighboring gene eukaryotic translation initiation factor 3, subunit F Neighboring gene TUB bipartite transcription factor Neighboring gene high mobility group protein B1 pseudogene Neighboring gene LIM domain only 1 Neighboring gene uncharacterized LOC120097351

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein. Koperniak TM, et al. J Neurochem, 2013 Feb. PMID 23157401
    2. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. Wang Y, et al. J Neurosci, 2009 Oct 7. PMID 19812337, Free PMC Article
    3. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Osman AA, et al. Mol Cell Neurosci, 2008 Jun. PMID 18420419, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest GH4C1 cells may possess unknown chaperone(s) allowing high surface alpha7 expression in the absence of known RIC3 splice variants.
      Title: Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein.
    2. Two rat RIC-3 isoforms allow surface alpha7 nicotinic receptor expression on non-permissive cell lines
      Title: Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein RIC-3
    Names
    putative alpha7-nAChR chaperone
    resistance to inhibitors of cholinesterase 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115045.3 → NP_001108517.1  protein RIC-3 isoform 1

      See identical proteins and their annotated locations for NP_001108517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A9K3Y6V4, B0B1T9, D3ZU01
      Related
      ENSRNOP00000020137.4, ENSRNOT00000020137.7
      Conserved Domains (1) summary
      pfam15361
      Location:15 → 164
      RIC3; Resistance to inhibitors of cholinesterase homolog 3

    2. NM_001277069.1 → NP_001263998.1  protein RIC-3 isoform 2

      See identical proteins and their annotated locations for NP_001263998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      B0B1T8
      Conserved Domains (1) summary
      pfam15361
      Location:19 → 164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      172465638..172521349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274190.1 → XP_063130260.1  protein RIC-3 isoform X1

    2. XM_039091014.2 → XP_038946942.1  protein RIC-3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials