Lrp10 LDL receptor related protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrp10provided by RGD
Official Full Name: LDL receptor related protein 10provided by RGD
Primary source: RGD:1310471
See related: EnsemblRapid:ENSRNOG00000011592 AllianceGenome:RGD:1310471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable low-density lipoprotein particle receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within inner ear development; lipid metabolic process; and lipid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human LRP10 (LDL receptor related protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 216.6), Adrenal (RPKM 137.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31891358..31897530)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27921335..27927507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33107706..33114831)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395560.1 → NP_001382489.1 low-density lipoprotein receptor-related protein 10 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KGU3, F7F3K1, Q496Z8

Related

ENSRNOP00000015468.6, ENSRNOT00000015468.7

Conserved Domains (3) summary

cd00041
Location:192 → 302

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:142 → 176

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl00049
Location:36 → 136

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

31891358..31897530

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274233.1 → XP_063130303.1 low-density lipoprotein receptor-related protein 10 isoform X1

UniProtKB/TrEMBL

Q496Z8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037777.1: Suppressed sequence

Description

NM_001037777.1: This RefSeq was removed because the sequence of the transcript differs from the reference genome due to a difference in repeat number within a VNTR.