Pdzk1 PDZ domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdzk1provided by RGD
Official Full Name: PDZ domain containing 1provided by RGD
Primary source: RGD:70924
See related: EnsemblRapid:ENSRNOG00000000096 AllianceGenome:RGD:70924
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clamp
Summary: Enables scavenger receptor binding activity. Predicted to be involved in several processes, including carnitine transport; positive regulation of protein targeting to membrane; and regulation of monoatomic ion transport. Predicted to act upstream of or within in utero embryonic development. Located in apical plasma membrane and microvillus membrane. Orthologous to several human genes including PDZK1 (PDZ domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 2508.0) and Liver (RPKM 234.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (187064995..187096348)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (184376161..184407514)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198965685..198999323)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor.
Title: PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor.
oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function
Title: Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.

Submit: New GeneRIF Correction

General gene information

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Markers

AI267131 (e-PCR)
- UniSTS:159152

BF387011 (e-PCR)
- UniSTS:244159

RH134273 (e-PCR)
- UniSTS:217555

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carnitine transport	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Names: C-terminal linking and modulating protein; NHERF-3; Na(+)/H(+) exchanger regulatory factor 3; PDZ domain-containing protein 1; dietary Pi-regulated RNA-1; diphor-1; na/Pi cotransporter C-terminal-associated protein 1; naPi-Cap1; sodium-hydrogen exchanger regulatory factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031712.1 → NP_113900.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3

See identical proteins and their annotated locations for NP_113900.1

Status: PROVISIONAL

Source sequence(s)

AF116896

UniProtKB/Swiss-Prot

O35234, Q6AZ21, Q9JJ40

UniProtKB/TrEMBL

A6K399

Related

ENSRNOP00000000107.5, ENSRNOT00000000107.8

Conserved Domains (2) summary

smart00228
Location:375 → 455

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:242 → 320

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...