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    Pak6 p21 (RAC1) activated kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pak6provided by RGD
    Official Full Name
    p21 (RAC1) activated kinase 6provided by RGD
    Primary source
    RGD:1306213
    See related
    EnsemblRapid:ENSRNOG00000007925 AllianceGenome:RGD:1306213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to starvation; intracellular signal transduction; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm and postsynaptic density. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK6 (p21 (RAC1) activated kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 32.9), Kidney (RPKM 23.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pak6 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126092576..126128320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105638248..105674399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110442175..110486317)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase B Neighboring gene uncharacterized LOC120101639 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C, beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prognostic significance of p21-activated kinase 6 expression in patients with clear cell renal cell carcinoma. Liu W, et al. Ann Surg Oncol, 2014 Dec. PMID 24715215
    2. Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury. Zhao W, et al. J Mol Histol, 2011 Jun. PMID 21541790
    3. miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats. Zhou Q, et al. Life Sci, 2020 Nov 1. PMID 32679145
    4. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. Furnari MA, et al. PLoS One, 2013. PMID 23593460, Free PMC Article
    5. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Nekrasova T, et al. Dev Biol, 2008 Oct 1. PMID 18675265

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats.
      Title: miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats.
    2. after injury, the expression of PAK6 was increased significantly in the astrocytes and neurons
      Title: Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 6
    Names
    p21 (CDKN1A)-activated kinase 6
    p21 protein (Cdc42/Rac)-activated kinase 6
    p21-activated kinase 6
    NP_001099968.1
    XP_038960475.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106498.2 → NP_001099968.1  serine/threonine-protein kinase PAK 6

      See identical proteins and their annotated locations for NP_001099968.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPB6, D3ZQ51
      Related
      ENSRNOP00000099466.1, ENSRNOT00000141685.1
      Conserved Domains (2) summary
      cd06659
      Location:385 → 681
      STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
      pfam00786
      Location:11 → 67
      PBD; P21-Rho-binding domain

    2. NM_001430001.1 → NP_001416930.1  serine/threonine-protein kinase PAK 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPB6, D3ZQ51

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126092576..126128320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104547.2 → XP_038960475.1  serine/threonine-protein kinase PAK 6 isoform X1

      Conserved Domains (2) summary
      cd06659
      Location:385 → 681
      STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
      pfam00786
      Location:11 → 67
      PBD; P21-Rho-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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