PEA15 proliferation and apoptosis adaptor protein 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PEA15provided by HGNC
Official Full Name: proliferation and apoptosis adaptor protein 15provided by HGNC
Primary source: HGNC:HGNC:8822
See related: Ensembl:ENSG00000162734 MIM:603434; AllianceGenome:HGNC:8822
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15
Summary: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Broad expression in brain (RPKM 413.0), fat (RPKM 91.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (160205384..160215372)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (159342460..159352445)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (160175174..160185162)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
Title: Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.
Title: PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.
Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates alpha5beta1 integrin endocytosis.
Title: Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis.
Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression.
Title: Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression.
ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15.
Title: ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15.
Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.
Title: Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.
This study identified EA15, MIR22, and LINC00472 may serve as the potential diagnostic markers of diabetic nephropathy.
Title: EA15, MIR22, LINC00472 as diagnostic markers for diabetic kidney disease.
Study results indicated that PEA15 expression was associated with clinicopathology and prognosis in gastric cancer and was regulated by AKT to participate in cisplatin resistance, indicating that it may be a potential target for overcoming cisplatin resistance in the treatment of gastric cancer.
Title: PEA‑15 contributes to the clinicopathology and AKT‑regulated cisplatin resistance in gastric cancer.
Data suggest that PED has a prominent role in HCC biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment.
Title: Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.
PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.
Title: The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T03437 (e-PCR)
- UniSTS:58395

A002L26 (e-PCR)
- UniSTS:47695

BCD1937 (e-PCR)
- UniSTS:45149

D1S1839E (e-PCR)
- UniSTS:150883

RH11797 (e-PCR)
- UniSTS:62828

D10Bir17 (e-PCR), detects polymorphism
- UniSTS:141482

D1S3374 (e-PCR)
- UniSTS:25554

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
part_of microtubule associated complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: astrocytic phosphoprotein PEA-15

Names: 15 kDa phosphoprotein enriched in astrocytes; homolog of mouse MAT-1 oncogene; mammary transforming gene 1, mouse, homolog of; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in diabetes; proliferation and apoptosis adaptor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297576.2 → NP_001284505.1 astrocytic phosphoprotein PEA-15 isoform a

See identical proteins and their annotated locations for NP_001284505.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK095879, AL121987, BC010469, BC022554, DA131259

Consensus CDS

CCDS72954.1

UniProtKB/TrEMBL

Q6FHL9

Related

ENSP00000357055.1, ENST00000368076.1

Conserved Domains (1) summary

cd08338
Location:23 → 106

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
NM_001297577.2 → NP_001284506.1 astrocytic phosphoprotein PEA-15 isoform b

See identical proteins and their annotated locations for NP_001284506.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

BC010469, BC022554, DA131259, DA707281

Consensus CDS

CCDS1199.1

UniProtKB/Swiss-Prot

B1AKZ3, O00511, Q15121

UniProtKB/TrEMBL

B1AKZ4, D3DVE5, Q6FHL9

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
NM_001297578.2 → NP_001284507.1 astrocytic phosphoprotein PEA-15 isoform c

See identical proteins and their annotated locations for NP_001284507.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate in-frame splice site in the 5' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AL121987, BC010469, BC022554, DA157938

Consensus CDS

CCDS76227.1

UniProtKB/TrEMBL

B1AKZ5, Q6FHL9

Related

ENSP00000357056.1, ENST00000368077.5

Conserved Domains (1) summary

cl14633
Location:2 → 63

DD; Death Domain Superfamily of protein-protein interaction domains
NM_003768.5 → NP_003759.1 astrocytic phosphoprotein PEA-15 isoform b

See identical proteins and their annotated locations for NP_003759.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

BC002426, BC010469, BC022554, DA131259

Consensus CDS

CCDS1199.1

UniProtKB/Swiss-Prot

B1AKZ3, O00511, Q15121

UniProtKB/TrEMBL

B1AKZ4, D3DVE5, Q6FHL9

Related

ENSP00000353660.5, ENST00000360472.9

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

RNA

NR_123724.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.

Source sequence(s)

BC010469, BC022554, DA131259, DA538845