FCRLB Fc receptor like B [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCRLBprovided by HGNC
Official Full Name: Fc receptor like Bprovided by HGNC
Primary source: HGNC:HGNC:26431
See related: Ensembl:ENSG00000162746 MIM:609251; AllianceGenome:HGNC:26431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2
Summary: FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (161721544..161728143)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (161065867..161072464)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161691334..161697933)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The aim of the study was to associate multiple polymorphisms within FCGR gene locus with IgA nephropathy in a large Chinese cohort.
Title: FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation
Title: FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
Expression analysis revealed FCRL2 mRNA only in placenta.FCRL2 is differentially expressed by transformed B cell lines.
Title: Cloning and characterization of the human FCRL2 gene.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Fc receptor-like B

Names: fc receptor homolog expressed in B cells protein 2; fc receptor-like and mucin-like protein 2; fc receptor-like protein 2; fc receptor-related protein Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002901.4 → NP_001002901.1 Fc receptor-like B isoform 1 precursor

See identical proteins and their annotated locations for NP_001002901.1

Status: VALIDATED

Source sequence(s)

AL359541

Consensus CDS

CCDS30927.1

UniProtKB/Swiss-Prot

A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7

Related

ENSP00000356925.2, ENST00000367948.7

Conserved Domains (3) summary

cd05752
Location:23 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:104 → 186

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:114 → 190

IG_like; Immunoglobulin like
NM_001288829.1 → NP_001275758.1 Fc receptor-like B isoform 2 precursor

See identical proteins and their annotated locations for NP_001275758.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as hFCRL2c1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AY670684, BQ014014, DQ021957

Consensus CDS

CCDS72963.1

UniProtKB/Swiss-Prot

Q6BAA4

Related

ENSP00000356923.3, ENST00000367946.7

Conserved Domains (3) summary

cd05752
Location:23 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:104 → 186

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:114 → 190

IG_like; Immunoglobulin like
NM_001288830.1 → NP_001275759.1 Fc receptor-like B isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as hFCRL2c2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AY670685, BQ014014, BX364259, DQ021957

Consensus CDS

CCDS72965.1

UniProtKB/Swiss-Prot

Q6BAA4

Related

ENSP00000356922.1, ENST00000367945.5

Conserved Domains (3) summary

cd05752
Location:16 → 93

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:97 → 179

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:107 → 183

IG_like; Immunoglobulin like
NM_001288831.1 → NP_001275760.1 Fc receptor-like B isoform 4 precursor

See identical proteins and their annotated locations for NP_001275760.1

Status: VALIDATED

Description

Transcript Variant: This variant (4, also known as hFCRL2b1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AY670686, BQ014014, DQ021957

Consensus CDS

CCDS72962.1

UniProtKB/Swiss-Prot

Q6BAA4

Related

ENSP00000338598.5, ENST00000336830.9

Conserved Domains (3) summary

cd05752
Location:23 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:104 → 186

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:114 → 190

IG_like; Immunoglobulin like
NM_001288832.1 → NP_001275761.1 Fc receptor-like B isoform 5 precursor

See identical proteins and their annotated locations for NP_001275761.1

Status: VALIDATED

Description

Transcript Variant: This variant (5, also known as hFCRL2b2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AY670687, BQ014014, BX364259, DQ021957

Consensus CDS

CCDS72964.1

UniProtKB/Swiss-Prot

Q6BAA4

Related

ENSP00000356921.3, ENST00000367944.3

Conserved Domains (3) summary

cd05752
Location:16 → 93

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:97 → 179

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:107 → 183

IG_like; Immunoglobulin like
NM_001320241.1 → NP_001307170.1 Fc receptor-like B isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).

Source sequence(s)

AK290733, AY670683, BQ014014

Consensus CDS

CCDS30927.1

UniProtKB/Swiss-Prot

A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7

Conserved Domains (3) summary

cd05752
Location:23 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:104 → 186

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:114 → 190

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

161721544..161728143

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

161065867..161072464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152378.1: Suppressed sequence

Description

NM_152378.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.