GPR176 G protein-coupled receptor 176 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR176provided by HGNC
Official Full Name: G protein-coupled receptor 176provided by HGNC
Primary source: HGNC:HGNC:32370
See related: Ensembl:ENSG00000166073 MIM:612183; AllianceGenome:HGNC:32370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HB-954
Summary: Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Expression: Broad expression in brain (RPKM 2.2), testis (RPKM 1.7) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q14-q15.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (39799008..39920266, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (37604203..37725586, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (40091209..40212467, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.
Title: GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.
The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy.
Title: The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy.
The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
Title: The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
Title: High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
Title: GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
Data suggest that Gpr176 is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior. [REVIEW]
Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-83477 (e-PCR)
- UniSTS:101961

RH120239 (e-PCR)
- UniSTS:132696

SHGC-31667 (e-PCR)
- UniSTS:29789

D15S146 (e-PCR), detects polymorphism
- UniSTS:51370

A008K26 (e-PCR)
- UniSTS:77519

RH17437 (e-PCR)
- UniSTS:60370

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in circadian behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 176

Names: probable G-protein coupled receptor 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271854.2 → NP_001258783.1 G-protein coupled receptor 176 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC012377, AC023908

Consensus CDS

CCDS61589.1

UniProtKB/Swiss-Prot

Q14439

Related

ENSP00000299092.3, ENST00000299092.4

Conserved Domains (1) summary

pfam00001
Location:78 → 318

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001271855.2 → NP_001258784.1 G-protein coupled receptor 176 isoform 3

See identical proteins and their annotated locations for NP_001258784.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC023908

Consensus CDS

CCDS61588.1

UniProtKB/Swiss-Prot

Q14439

Related

ENSP00000439361.1, ENST00000543580.7

Conserved Domains (1) summary

pfam00001
Location:13 → 274

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_007223.3 → NP_009154.1 G-protein coupled receptor 176 isoform 1

See identical proteins and their annotated locations for NP_009154.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC012377, AC023908

Consensus CDS

CCDS10051.1

UniProtKB/Swiss-Prot

B4DZ23, H9NIL9, J3KNC6, Q14439, Q6NXF6

Related

ENSP00000453076.1, ENST00000561100.2

Conserved Domains (1) summary

pfam00001
Location:58 → 319

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

39799008..39920266 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017021878.3 → XP_016877367.1 G-protein coupled receptor 176 isoform X2

Conserved Domains (2) summary

cd14964
Location:1 → 14

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 168

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017021873.3 → XP_016877362.1 G-protein coupled receptor 176 isoform X1

Conserved Domains (1) summary

pfam00001
Location:26 → 287

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_011521167.4 → XP_011519469.1 G-protein coupled receptor 176 isoform X1

See identical proteins and their annotated locations for XP_011519469.1

Conserved Domains (1) summary

pfam00001
Location:26 → 287

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_017021874.3 → XP_016877363.1 G-protein coupled receptor 176 isoform X2

Conserved Domains (2) summary

cd14964
Location:1 → 14

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 168

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_024449835.2 → XP_024305603.1 G-protein coupled receptor 176 isoform X2

Conserved Domains (2) summary

cd14964
Location:1 → 14

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 168

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily