Etnk2 ethanolamine kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etnk2provided by MGI
Official Full Name: ethanolamine kinase 2provided by MGI
Primary source: MGI:MGI:2443760
See related: Ensembl:ENSMUSG00000070644 AllianceGenome:MGI:2443760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eki2; Tuc1; EKI 2; 4933417N20Rik
Summary: Enables ethanolamine kinase activity. Involved in phosphorylation. Acts upstream of or within several processes, including in utero embryonic development; phosphatidylethanolamine biosynthetic process; and placenta development. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; heart; intestine; liver; and lung. Orthologous to human ETNK2 (ethanolamine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 89.4), ovary adult (RPKM 18.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.91 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133291308..133308056)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133363463..133380318)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

No abnormalities were detected in the Eki2-deficient mice with regard to embryonic and adult testis morphology, differentiation, function, or fertility.
Title: Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice.
Expression restricted to the Sertoli cells of the developing testis.
Title: Eki2 is upregulated specifically in the testis during mouse sex determination.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

Etnk2 (e-PCR), detects polymorphism
- UniSTS:274177

RH135965 (e-PCR)
- UniSTS:209961

D1Mit30 (e-PCR), detects polymorphism
- UniSTS:128654

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables choline kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylethanolamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ethanolamine kinase 2

Names: ethanolamine kinase-like protein; putative ethanolamine kinase

NP_001406522.1

EC 2.7.1.82

NP_780652.2

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419593.1 → NP_001406522.1 ethanolamine kinase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC068906
NM_175443.6 → NP_780652.2 ethanolamine kinase 2

See identical proteins and their annotated locations for NP_780652.2

Status: VALIDATED

Source sequence(s)

AC068906

Consensus CDS

CCDS15296.2

UniProtKB/Swiss-Prot

A7MCT6, B7ZNN6, D3Z771, Q6XRG2

Related

ENSMUSP00000114272.3, ENSMUST00000135222.9

Conserved Domains (2) summary

PLN02236
Location:60 → 378

PLN02236; choline kinase

cd05157
Location:82 → 374

ETNK_euk; Euykaryotic Ethanolamine kinase