Nabp2 nucleic acid binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nabp2provided by MGI
Official Full Name: nucleic acid binding protein 2provided by MGI
Primary source: MGI:MGI:1917167
See related: Ensembl:ENSMUSG00000025374 AllianceGenome:MGI:1917167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSB1; Obfc2b; 2610036N15Rik
Summary: Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Involved in DNA repair and positive regulation of telomere capping. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 13.1), whole brain E14.5 (RPKM 12.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.55 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128237263..128247426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128401394..128411548, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obfc2b deficiency does not affect initiation of DNA damage checkpoints, Atm activation, or the maintenance of genomic stability in B lymphocytes & primary fibroblasts. Its role in embryogenesis limited to cell types contributing to bone formation.
Title: The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SOSS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SOSS complex	ISO Inferred from Sequence Orthology more info
part_of SOSS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SOSS complex subunit B1

Names: SOSS-B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B; sensor of single-strand DNA complex subunit B1; sensor of ssDNA subunit B1; single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358972.1 → NP_001345901.1 SOSS complex subunit B1 isoform 1

Status: VALIDATED

Source sequence(s)

AC090489, BE988804, BX519720, CX238225

Consensus CDS

CCDS24276.1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
NM_001358973.1 → NP_001345902.1 SOSS complex subunit B1 isoform 2

Status: VALIDATED

Source sequence(s)

AC090489, BE988804, BX519720, CX238225

Conserved Domains (1) summary

PRK14971
Location:7 → 80

PRK14971; DNA polymerase III subunit gamma/tau
NM_027257.2 → NP_081533.1 SOSS complex subunit B1 isoform 1

See identical proteins and their annotated locations for NP_081533.1

Status: VALIDATED

Source sequence(s)

BE988804, BX519720, BY250791, CX238225

Consensus CDS

CCDS24276.1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Related

ENSMUSP00000026439.8, ENSMUST00000026439.14

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128237263..128247426 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514067.4 → XP_006514130.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_006514130.1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_036155988.1 → XP_036011881.1 SOSS complex subunit B1 isoform X1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_006514066.4 → XP_006514129.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_006514129.1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_030245253.2 → XP_030101113.1 SOSS complex subunit B1 isoform X1

UniProtKB/Swiss-Prot

Q8R2Y9

UniProtKB/TrEMBL

E9Q199

Related

ENSMUSP00000128634.2, ENSMUST00000164199.8

Conserved Domains (2) summary

PRK14971
Location:106 → 179

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_030245254.2 → XP_030101114.1 SOSS complex subunit B1 isoform X2

Conserved Domains (1) summary

PRK14971
Location:7 → 80

PRK14971; DNA polymerase III subunit gamma/tau