Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals3bpprovided by MGI
Official Full Name: lectin, galactoside-binding, soluble, 3 binding proteinprovided by MGI
Primary source: MGI:MGI:99554
See related: Ensembl:ENSMUSG00000033880 AllianceGenome:MGI:99554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 90K; CyCAP; Ppicap; MAC-2BP; Tango10b
Summary: Predicted to enable scavenger receptor activity. Predicted to be involved in cell adhesion and vesicle-mediated transport. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and liver and biliary system. Orthologous to human LGALS3BP (galectin 3 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 204.1), duodenum adult (RPKM 185.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.14 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118283573..118292787, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (118392747..118401959, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex.
Title: West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex.
Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
Title: Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
Physical Activity Attenuates the Obesity-Induced Dysregulated Expression of Brown Adipokines in Murine Interscapular Brown Adipose Tissue.
Title: Physical Activity Attenuates the Obesity-Induced Dysregulated Expression of Brown Adipokines in Murine Interscapular Brown Adipose Tissue.
Using a mouse stasis model of venous thrombosis, we found that gal3bp and gal3 were localized on vein wall, red blood cells, platelets, and microparticles, whereas leukocytes expressed gal3 only.
Title: The role of galectin-3 and galectin-3-binding protein in venous thrombosis.
These findings suggest a novel immunoinhibitory function for LGALS3BP that might be important for immune evasion of tumor cells during cancer progression.
Title: Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
Data give novel evidence that CyCAP regulates the post-translational modification of tissue transglutaminase through its colocalization with calnexin in endoplasmic reticulum.
Title: Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.
CyCAP-deficient mice spontaneously and after challenge with carcinogen develop significantly more colorectal mucosal hyperplasia, an early stage in murine colonic carcinogenesis
Title: Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane.
Cyclophilin C-associated protein is expressed in skin and during wound repair. It is regulated by IFNgamma and may function on immune defense in macrophages, lymphocytes, dermal fibroblasts and keratinocytes during wound healing.
Title: Cyclophilin C-associated protein is up-regulated during wound healing.
CyC-AP is an important factor for the regulation of MMP-13 expression
Title: Cyclophilin C-associated protein is a mediator for fibronectin fragment-induced matrix metalloproteinase-13 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppicap (e-PCR), detects polymorphism
- UniSTS:144253

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables scavenger receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-3-binding protein

Names: cyp-C-associated protein; mama; peptidylprolyl isomerase C-associated protein

NP_035280.1

EC 3.6.1.6

XP_036012322.1

EC 3.6.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011150.3 → NP_035280.1 galectin-3-binding protein precursor

See identical proteins and their annotated locations for NP_035280.1

Status: VALIDATED

Source sequence(s)

AK079915, BP765555

Consensus CDS

CCDS25701.1

UniProtKB/Swiss-Prot

O35649, Q07797, Q3U631, Q3U8K4, Q3UDL5

Related

ENSMUSP00000035579.4, ENSMUST00000043722.10

Conserved Domains (3) summary

smart00875
Location:261 → 358

BACK; BTB And C-terminal Kelch

smart00202
Location:24 → 124

SR; Scavenger receptor Cys-rich

pfam00530
Location:29 → 124

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

118283573..118292787 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156429.1 → XP_036012322.1 galectin-3-binding protein isoform X1

Conserved Domains (3) summary

smart00202
Location:56 → 156

SR; Scavenger receptor Cys-rich

cl38908
Location:168 → 279

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl28903
Location:288 → 361

BACK; BACK (BTB and C-terminal Kelch) domain