Cnot1 CCR4-NOT transcription complex, subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnot1provided by MGI
Official Full Name: CCR4-NOT transcription complex, subunit 1provided by MGI
Primary source: MGI:MGI:2442402
See related: Ensembl:ENSMUSG00000036550 AllianceGenome:MGI:2442402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D830048B13; 6030411K04Rik
Summary: Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 29.9), placenta adult (RPKM 21.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D1; 8 47.18 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (96445559..96534741, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95718931..95808113, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression.
Title: Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression.
CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner.
Title: CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner.
CCR4-NOT complex-mediated regulation of gene expression has significant effects on proper adipocyte function, including insulin sensitivity, lipid metabolism, and control of body temperature.
Title: The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity.
Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
Title: Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
Title: Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs.
Title: Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cnot1 (e-PCR), detects polymorphism
- UniSTS:547198

NoName (e-PCR)
- UniSTS:235972

NoName (e-PCR)
- UniSTS:235974

NoName (e-PCR)
- UniSTS:235976

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IEA Inferred from Electronic Annotation more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(A)-specific ribonuclease activity	IEA Inferred from Electronic Annotation more info
contributes_to poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytoplasmic mRNA processing body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic mRNA processing body assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in trophectodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCR4-NOT core complex	IEA Inferred from Electronic Annotation more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 1

Names: CCR4-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205226.2 → NP_001192155.1 CCR4-NOT transcription complex subunit 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC113951, AC127300

Consensus CDS

CCDS85589.1

UniProtKB/TrEMBL

A0A1D5RMJ8, B2RXR3

Related

ENSMUSP00000148807.2, ENSMUST00000211887.2

Conserved Domains (5) summary

pfam04054
Location:1991 → 2346

Not1; CCR4-Not complex component, Not1

pfam12842
Location:1382 → 1527

DUF3819; Domain of unknown function (DUF3819)

pfam16415
Location:1081 → 1305

CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain

pfam16417
Location:813 → 997

CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain

pfam16418
Location:498 → 654

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_001372351.1 → NP_001359280.1 CCR4-NOT transcription complex subunit 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC113951, AC127300

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:834 → 2370

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_001372353.1 → NP_001359282.1 CCR4-NOT transcription complex subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC113951, AC127300

Consensus CDS

CCDS90442.1

UniProtKB/TrEMBL

B2RXR3

Related

ENSMUSP00000096073.5, ENSMUST00000098473.11

Conserved Domains (2) summary

COG5103
Location:840 → 2369

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_153164.4 → NP_694804.3 CCR4-NOT transcription complex subunit 1 isoform 1

See identical proteins and their annotated locations for NP_694804.3

Status: VALIDATED

Source sequence(s)

AC113951, AC127300

Consensus CDS

CCDS57635.1

UniProtKB/TrEMBL

B2RXR3, B7ZWL1

Related

ENSMUSP00000063565.9, ENSMUST00000068452.10

Conserved Domains (5) summary

pfam04054
Location:1993 → 2301

Not1; CCR4-Not complex component, Not1

pfam12842
Location:1384 → 1529

DUF3819; Domain of unknown function (DUF3819)

pfam16415
Location:1083 → 1307

CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain

pfam16417
Location:815 → 999

CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_178078.3 → NP_835179.1 CCR4-NOT transcription complex subunit 1 isoform 2

See identical proteins and their annotated locations for NP_835179.1

Status: VALIDATED

Source sequence(s)

AC113951, AC127300

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (5) summary

pfam04054
Location:1993 → 2348

Not1; CCR4-Not complex component, Not1

pfam12842
Location:1384 → 1529

DUF3819; Domain of unknown function (DUF3819)

pfam16415
Location:1083 → 1307

CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain

pfam16417
Location:815 → 999

CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

96445559..96534741 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530870.2 → XP_006530933.1 CCR4-NOT transcription complex subunit 1 isoform X1

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:840 → 2376

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
XM_036153965.1 → XP_036009858.1 CCR4-NOT transcription complex subunit 1 isoform X5

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:834 → 2363

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
XM_036153964.1 → XP_036009857.1 CCR4-NOT transcription complex subunit 1 isoform X4

UniProtKB/Swiss-Prot

B2RY28, Q3UPB7, Q6ZQ08, Q8BSB4, Q8BXB2, Q8C0H2, Q8K3D8

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:839 → 2368

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
XM_006530871.3 → XP_006530934.1 CCR4-NOT transcription complex subunit 1 isoform X2

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:839 → 2375

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
XM_006530872.3 → XP_006530935.1 CCR4-NOT transcription complex subunit 1 isoform X3

UniProtKB/TrEMBL

B2RXR3

Conserved Domains (2) summary

COG5103
Location:835 → 2371

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat