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    Ptpn20 protein tyrosine phosphatase, non-receptor type 20 [ Mus musculus (house mouse) ]

    Gene ID: 19256, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptpn20provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 20provided by MGI
    Primary source
    MGI:MGI:1196295
    See related
    Ensembl:ENSMUSG00000021940 AllianceGenome:MGI:1196295
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    typ
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in centriolar satellite. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in epididymis; metanephros; submandibular gland; and testis. Orthologous to human PTPN20 (protein tyrosine phosphatase non-receptor type 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 17.2) See more
    Orthologs
    human all
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    Genomic context

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    See Ptpn20 in Genome Data Viewer
    Location:
    14 B; 14 20.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33311150..33362711)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33589193..33640754)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_36354 Neighboring gene predicted gene, 26228 Neighboring gene STARR-seq mESC enhancer starr_36355 Neighboring gene STARR-seq mESC enhancer starr_36356 Neighboring gene RIKEN cDNA 4930503F20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes. Ohsugi M, et al. J Biol Chem, 1997 Dec 26. PMID 9407093
    2. Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. Xu H, et al. Fluids Barriers CNS, 2022 Jun 3. PMID 35658898, Free PMC Article
    3. The histone H3K9 methyltransferase G9a regulates tendon formation during development. Wada S, et al. Sci Rep, 2024 Sep 5. PMID 39237663, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
      Title: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphangiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 20
    Names
    testis-specific tyrosine phosphatase
    NP_033004.1
    XP_006518791.1
    XP_006518793.1
    XP_011243298.1
    XP_030103554.1
    XP_030103555.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008978.2 → NP_033004.1  tyrosine-protein phosphatase non-receptor type 20

      See identical proteins and their annotated locations for NP_033004.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154465
      Consensus CDS
      CCDS36870.1
      UniProtKB/Swiss-Prot
      A4QPF6, O55082
      Related
      ENSMUSP00000022508.7, ENSMUST00000022508.8
      Conserved Domains (2) summary
      smart00194
      Location:165 → 417
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:191 → 417
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33311150..33362711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518728.4 → XP_006518791.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

      See identical proteins and their annotated locations for XP_006518791.1

      Conserved Domains (1) summary
      cl28904
      Location:251 → 457
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_011244996.3 → XP_011243298.1  tyrosine-protein phosphatase non-receptor type 20 isoform X2

      Conserved Domains (1) summary
      smart00194
      Location:202 → 240
      PTPc; Protein tyrosine phosphatase, catalytic domain

    3. XM_030247694.2 → XP_030103554.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:23 → 130
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_006518730.1 → XP_006518793.1  tyrosine-protein phosphatase non-receptor type 20 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:40 → 246
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_030247695.1 → XP_030103555.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:23 → 130
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_383149.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55082.1 GenPept UniProtKB/Swiss-Prot:O55082

    Gene LinkOut

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