Tshz2 teashirt zinc finger family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tshz2provided by MGI
Official Full Name: teashirt zinc finger family member 2provided by MGI
Primary source: MGI:MGI:2153084
See related: Ensembl:ENSMUSG00000047907 AllianceGenome:MGI:2153084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsh2; Mtsh2; Zfp218; Sdccag33l; mKIAA4248; teashirt2; B830045G17; 2900073F20Rik
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including forelimb; ganglionic eminence; genitourinary system; heart valve; and limb bud. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in genital fat pad adult (RPKM 8.3), bladder adult (RPKM 7.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 89.47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (169474430..169914671)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (169632509..170072751)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tshz2 and Tshz3 genes were detected in mouse ureters.
Title: Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.
role for mTsh genes in the establishment of regional identity and specification of cell types in the developing and adult forebrain
Title: Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
Title: Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Transposon induced (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: teashirt homolog 2

Names: SDCCAG33-like protein; serologically defined colon cancer antigen 33 like; teashirt 2; zinc finger protein 218

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363022.2 → NP_001349951.1 teashirt homolog 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL731822, AL731826

Consensus CDS

CCDS50805.1

UniProtKB/Swiss-Prot

Q5DTF1, Q68FE9, Q6AXH5, Q9JL71

Conserved Domains (1) summary

cd00086
Location:838 → 906

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001363023.2 → NP_001349952.1 teashirt homolog 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL731822, AL731826

Consensus CDS

CCDS50805.1

UniProtKB/Swiss-Prot

Q5DTF1, Q68FE9, Q6AXH5, Q9JL71

Related

ENSMUSP00000104787.3, ENSMUST00000109159.3

Conserved Domains (1) summary

cd00086
Location:838 → 906

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_080455.4 → NP_536703.2 teashirt homolog 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL731822, AL731826

Consensus CDS

CCDS50805.1

UniProtKB/Swiss-Prot

Q5DTF1, Q68FE9, Q6AXH5, Q9JL71

Related

ENSMUSP00000104785.2, ENSMUST00000109157.2

Conserved Domains (1) summary

cd00086
Location:838 → 906

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_177659.2 → NP_808327.1 teashirt homolog 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.

Source sequence(s)

AL731822, AL731826

Conserved Domains (2) summary

cd00086
Location:838 → 906

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:218 → 240

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

169474430..169914671

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161701.1 → XP_036017594.1 teashirt homolog 2 isoform X4

Conserved Domains (2) summary

cd00086
Location:838 → 906

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:218 → 240

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006499424.5 → XP_006499487.2 teashirt homolog 2 isoform X1

Conserved Domains (2) summary

cd00086
Location:858 → 926

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:238 → 260

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006499426.5 → XP_006499489.2 teashirt homolog 2 isoform X3

Conserved Domains (2) summary

cd00086
Location:858 → 926

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:238 → 260

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006499423.5 → XP_006499486.2 teashirt homolog 2 isoform X1

Conserved Domains (2) summary

cd00086
Location:858 → 926

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:238 → 260

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006499425.5 → XP_006499488.2 teashirt homolog 2 isoform X2

Conserved Domains (2) summary

cd00086
Location:858 → 926

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:238 → 260

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030250745.2 → XP_030106605.1 teashirt homolog 2 isoform X1

Conserved Domains (2) summary

cd00086
Location:858 → 926

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:238 → 260

ZF_C2H2; C2H2 Zn finger [structural motif]