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    Tinagl1 tubulointerstitial nephritis antigen-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 94242, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tinagl1provided by MGI
    Official Full Name
    tubulointerstitial nephritis antigen-like 1provided by MGI
    Primary source
    MGI:MGI:2137617
    See related
    Ensembl:ENSMUSG00000028776 AllianceGenome:MGI:2137617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ1; AZ-1; Arg1; Lcn7; TARP; Tinagl; 1110021J17Rik
    Summary
    Enables laminin binding activity. Predicted to be involved in proteolysis. Located in cytoplasm. Is expressed in several structures, including adrenal gland; blastocyst; brain ventricle; early embryo; and submandibular gland primordium. Orthologous to human TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 158.0), placenta adult (RPKM 140.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tinagl1 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130059393..130068915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130165600..130175122, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hypocretin (orexin) receptor 1 Neighboring gene predicted gene, 40259 Neighboring gene predicted gene, 52490 Neighboring gene leucine decarboxylase 1 Neighboring gene predicted gene, 46724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling. Sato Y, et al. Biochim Biophys Acta Mol Cell Res, 2022 Sep. PMID 35597451
    2. An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta -hydroxylase in adrenocortical cells. Mukai K, et al. J Biol Chem, 2003 May 9. PMID 12600995
    3. Adrenocortical zonation factor 1 is a novel matricellular protein promoting integrin-mediated adhesion of adrenocortical and vascular smooth muscle cells. Li D, et al. FEBS J, 2007 May. PMID 17425658
    4. Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice. Tajiri Y, et al. Biol Reprod, 2010 Feb. PMID 19776386
    5. Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice. Takahashi A, et al. J Reprod Dev, 2016. PMID 26522507, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
      Title: Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
    2. Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
      Title: Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
    3. Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes.
      Title: Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes.
    4. Tinagl1 is related to fertility in adult females but is not essential for either fertilization or preimplantation development in vitro
      Title: Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice.
    5. Data show that endothelial cell lines SVEC but not MB114 cells express low levels of endogenous LCN7 mRNA and that overexpression significantly increased LCN7 mRNA over basal levels in both cell lines.
      Title: Lipocalin-7 is a matricellular regulator of angiogenesis.
    6. results suggest that tubulointerstitial nephritis antigen-like 1(Tinagl1) functions during the postimplantation period
      Title: Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice.
    7. In mouse embryos, the expression of both Tinagl1 mRNA and TINAGL1 protein was increased just prior to implantation. During postimplantation, TINAGL1 expression was restricted to extraembryonic regions.
      Title: Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the Reichert membrane at postimplantation in the mouse.
    8. Collectively with the putative role of AZ-1 in the adrenocortical zonation, we propose that AZ-1 potentially regulates functions of adrenocortical and VSM cells by modulating cell-matrix interactions
      Title: Adrenocortical zonation factor 1 is a novel matricellular protein promoting integrin-mediated adhesion of adrenocortical and vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables laminin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulointerstitial nephritis antigen-like
    Names
    adrenocortical zonation factor 1
    androgen-regulated gene 1 protein
    tubulointerstitial nephritis antigen-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168333.1 → NP_001161805.1  tubulointerstitial nephritis antigen-like precursor

      See identical proteins and their annotated locations for NP_001161805.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB050626, AL606925
      Consensus CDS
      CCDS18708.2
      UniProtKB/Swiss-Prot
      Q99JR5, Q9EQT9
      UniProtKB/TrEMBL
      H3BJ97
      Related
      ENSMUSP00000101621.3, ENSMUST00000105999.9
      Conserved Domains (3) summary
      cd02620
      Location:203 → 454
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:53 → 93
      Somatomedin_B; Somatomedin B domain
      cl17735
      Location:104 → 152
      VWC; von Willebrand factor type C domain

    2. NM_023476.3 → NP_075965.2  tubulointerstitial nephritis antigen-like precursor

      See identical proteins and their annotated locations for NP_075965.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL606925
      Consensus CDS
      CCDS18708.2
      UniProtKB/Swiss-Prot
      Q99JR5, Q9EQT9
      UniProtKB/TrEMBL
      H3BJ97
      Related
      ENSMUSP00000101620.2, ENSMUST00000105998.8
      Conserved Domains (3) summary
      cd02620
      Location:203 → 454
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:53 → 93
      Somatomedin_B; Somatomedin B domain
      cl17735
      Location:104 → 152
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130059393..130068915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JR5.1 GenPept UniProtKB/Swiss-Prot:Q99JR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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