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    Rhof ras homolog family member F (in filopodia) [ Mus musculus (house mouse) ]

    Gene ID: 23912, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rhofprovided by MGI
    Official Full Name
    ras homolog family member F (in filopodia)provided by MGI
    Primary source
    MGI:MGI:1345629
    See related
    Ensembl:ENSMUSG00000029449 AllianceGenome:MGI:1345629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rif; Arhf; Ifld1
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cytosol and plasma membrane. Orthologous to human RHOF (ras homolog family member F, filopodia associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 35.2), small intestine adult (RPKM 26.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhof in Genome Data Viewer
    Location:
    5 F; 5 62.77 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123256243..123270692, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123118180..123141808, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123489053-123489354 Neighboring gene predicted gene, 42023 Neighboring gene MORN repeat containing 3 Neighboring gene STARR-seq mESC enhancer starr_14309 Neighboring gene STARR-positive B cell enhancer ABC_E6376 Neighboring gene predicted gene 6444 Neighboring gene transmembrane protein 120B Neighboring gene STARR-seq mESC enhancer starr_14311 Neighboring gene STARR-seq mESC enhancer starr_14312 Neighboring gene STARR-positive B cell enhancer ABC_E10349 Neighboring gene STARR-positive B cell enhancer ABC_E4788 Neighboring gene STARR-positive B cell enhancer ABC_E6377 Neighboring gene STARR-positive B cell enhancer ABC_E1060 Neighboring gene STARR-positive B cell enhancer ABC_E8079 Neighboring gene STARR-seq mESC enhancer starr_14314 Neighboring gene expressed sequence AI480526 Neighboring gene STARR-positive B cell enhancer ABC_E2763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123591600-123591709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599408-123599706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599709-123599818 Neighboring gene STARR-positive B cell enhancer ABC_E6378 Neighboring gene SET domain containing 1B Neighboring gene predicted gene, 54284

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rhof promotes murine marginal zone B cell development. Kishimoto M, et al. Nagoya J Med Sci, 2014 Aug. PMID 25741038, Free PMC Article
    2. The small GTPase Rif is dispensable for platelet filopodia generation in mice. Goggs R, et al. PLoS One, 2013. PMID 23359340, Free PMC Article
    3. KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. Shaverdashvili K, et al. PLoS One, 2019. PMID 30998758, Free PMC Article
    4. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors. Goh WI, et al. J Biol Chem, 2011 Apr 15. PMID 21339294, Free PMC Article
    5. The Rho family GTPase Rif induces filopodia through mDia2. Pellegrin S, et al. Curr Biol, 2005 Jan 26. PMID 15668168

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RHOF is required for NFkappaB activation by KLF4 in esophageal keratinocytes and is also important for esophageal keratinocyte proliferation and migration.
      Title: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.
    2. small GTPase Rif does not appear to be critical for platelet function in mice. Functional overlap between Rif and other small GTPases may be responsible for the non-essential role of Rif in platelets
      Title: The small GTPase Rif is dispensable for platelet filopodia generation in mice.
    3. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
      Title: Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoF
    Names
    induced in fatty liver dystrophy 1
    ras homolog gene family, member f (in filopodia)
    NP_780301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175092.3 → NP_780301.1  rho-related GTP-binding protein RhoF

      See identical proteins and their annotated locations for NP_780301.1

      Status: VALIDATED

      Source sequence(s)
      AC158114, CK617811, DV646753
      Consensus CDS
      CCDS39263.1
      UniProtKB/Swiss-Prot
      Q8BYP3
      UniProtKB/TrEMBL
      Q4VA10
      Related
      ENSMUSP00000031401.6, ENSMUST00000031401.6
      Conserved Domains (1) summary
      cd04132
      Location:17 → 211
      Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123256243..123270692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYP3.1 GenPept UniProtKB/Swiss-Prot:Q8BYP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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