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    Klf14 Kruppel-like transcription factor 14 [ Mus musculus (house mouse) ]

    Gene ID: 619665, updated on 27-Nov-2024

    Summary

    Official Symbol
    Klf14provided by MGI
    Official Full Name
    Kruppel-like transcription factor 14provided by MGI
    Primary source
    MGI:MGI:3577024
    See related
    Ensembl:ENSMUSG00000073209 AllianceGenome:MGI:3577024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BTEB5; 5330411L03Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within positive regulation of sphingolipid mediated signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skin. Orthologous to human KLF14 (KLF transcription factor 14). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See Klf14 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30932956..30935925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30956021..30958990, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit gamma 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13 Neighboring gene STARR-seq mESC enhancer starr_15475 Neighboring gene predicted gene, 40359 Neighboring gene microRNA 29a

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 14
    Names
    Kruppel-like factor 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135093.1NP_001128565.1  Krueppel-like factor 14

      See identical proteins and their annotated locations for NP_001128565.1

      Status: VALIDATED

      Source sequence(s)
      AC121800
      Consensus CDS
      CCDS51744.1
      UniProtKB/Swiss-Prot
      Q19A41
      Related
      ENSMUSP00000099122.4, ENSMUST00000101589.5
      Conserved Domains (3) summary
      COG5048
      Location:198283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:200219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:241266
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30932956..30935925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)