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    Tmc3 transmembrane channel-like gene family 3 [ Mus musculus (house mouse) ]

    Gene ID: 233424, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmc3provided by MGI
    Official Full Name
    transmembrane channel-like gene family 3provided by MGI
    Primary source
    MGI:MGI:2669033
    See related
    Ensembl:ENSMUSG00000038540 AllianceGenome:MGI:2669033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030203A06
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be located in plasma membrane. Is expressed in bone and rib. Orthologous to human TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.4), cerebellum adult (RPKM 1.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmc3 in Genome Data Viewer
    Location:
    7 D3; 7 47.43 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83234112..83276060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83584904..83626852)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19407 Neighboring gene STARR-positive B cell enhancer mm9_chr7:90574679-90574980 Neighboring gene retinoblastoma binding protein 6 pseudogene Neighboring gene predicted gene 10610 Neighboring gene STARR-seq mESC enhancer starr_19409 Neighboring gene predicted gene, 16638 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:90803780-90804044 Neighboring gene StAR related lipid transfer domain containing 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:90809590-90809791 Neighboring gene interleukin 16 Neighboring gene STARR-positive B cell enhancer ABC_E8840 Neighboring gene 3-phosphoglycerate dehydrogenase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. Beurg M, et al. J Gen Physiol, 2014 Jul. PMID 24981230, Free PMC Article
    2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
    3. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177695.4 → NP_808363.3  transmembrane channel-like protein 3

      See identical proteins and their annotated locations for NP_808363.3

      Status: VALIDATED

      Source sequence(s)
      AC158576, AY236491, AY263157
      Consensus CDS
      CCDS40012.1
      UniProtKB/Swiss-Prot
      Q7TN63, Q7TQ69
      UniProtKB/TrEMBL
      F8VQI4
      Related
      ENSMUSP00000046028.8, ENSMUST00000039317.14
      Conserved Domains (1) summary
      pfam07810
      Location:505 → 611
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      83234112..83276060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507591.3 → XP_006507654.1  transmembrane channel-like protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q7TN63, Q7TQ69
      UniProtKB/TrEMBL
      E9Q6Y0
      Related
      ENSMUSP00000130348.2, ENSMUST00000164944.2
      Conserved Domains (1) summary
      pfam07810
      Location:500 → 615
      TMC; TMC domain

    RNA

    1. XR_001785530.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQ69.1 GenPept UniProtKB/Swiss-Prot:Q7TQ69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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