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    Prss54 serine protease 54 [ Mus musculus (house mouse) ]

    Gene ID: 70993, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prss54provided by MGI
    Official Full Name
    serine protease 54provided by MGI
    Primary source
    MGI:MGI:1918243
    See related
    Ensembl:ENSMUSG00000048400 AllianceGenome:MGI:1918243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klkbl4; 4931432M23Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 70.8) See more
    Orthologs
    human all
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    Genomic context

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    See Prss54 in Genome Data Viewer
    Location:
    8 D1; 8 47.12 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96285694..96302965, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95559066..95576337, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene coiled-coil domain containing 113 Neighboring gene STARR-seq mESC enhancer starr_22390 Neighboring gene G patch domain and KOW motifs pseudogene Neighboring gene STARR-seq mESC enhancer starr_22391 Neighboring gene predicted gene, 31518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†. Shen C, et al. Biol Reprod, 2022 Oct 11. PMID 35863763
    2. The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†. Holcomb RJ, et al. Biol Reprod, 2020 Feb 12. PMID 31403672, Free PMC Article
    3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in micedagger.
      Title: Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.
    2. The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertilitydagger.
      Title: The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine protease 54
    Names
    plasma kallikrein-like protein 4
    protease, serine 54

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310539.1 → NP_001297468.1  inactive serine protease 54

      See identical proteins and their annotated locations for NP_001297468.1

      Status: VALIDATED

      Source sequence(s)
      AC102555, BC145787, BY716181
      Consensus CDS
      CCDS80916.1
      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Related
      ENSMUSP00000058859.7, ENSMUST00000052690.13
      Conserved Domains (1) summary
      cd00190
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96285694..96302965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531368.4 → XP_006531431.1  inactive serine protease 54 isoform X2

      See identical proteins and their annotated locations for XP_006531431.1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_017312965.2 → XP_017168454.1  inactive serine protease 54 isoform X2

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_017312964.2 → XP_017168453.1  inactive serine protease 54 isoform X2

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_006531366.3 → XP_006531429.1  inactive serine protease 54 isoform X2

      See identical proteins and their annotated locations for XP_006531429.1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. XM_006531365.3 → XP_006531428.1  inactive serine protease 54 isoform X1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:88 → 299
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027640.1: Suppressed sequence

      Description
      NM_027640.1: This RefSeq has been removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M756.1 GenPept UniProtKB/Swiss-Prot:Q7M756

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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