Prmt5 protein arginine methyltransferase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prmt5provided by RGD
Official Full Name: protein arginine methyltransferase 5provided by RGD
Primary source: RGD:1309053
See related: EnsemblRapid:ENSRNOG00000012046 AllianceGenome:RGD:1309053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Skb1; Hrmt1l5
Summary: Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; negative regulation of gene expression via chromosomal CpG island methylation; and positive regulation of oligodendrocyte differentiation. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 128.5), Brain (RPKM 109.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31938927..31948318, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27968893..27978291, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33156508..33165893, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion.
Title: Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion.
Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/beta-catenin.
Title: Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin.
Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage.
Title: Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage.
These data provide the first direct experimental evidence that PRMT5, a type II arginine methylase, is involved in the control of transcription and proliferation.
Title: Negative regulation of transcription by the type II arginine methyltransferase PRMT5.
analysis of structural insights into protein arginine symmetric dimethylation by PRMT5
Title: Structural insights into protein arginine symmetric dimethylation by PRMT5.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
Title: Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AQ104 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AR3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K37 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription termination	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-arginine N-methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
part_of methylosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein arginine N-methyltransferase 5

Names: HMT1 hnRNP methyltransferase-like 5; SKB1 homolog

NP_001102337.2

EC 2.1.1.125

XP_038949474.1

EC 2.1.1.125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108867.2 → NP_001102337.2 protein arginine N-methyltransferase 5

See identical proteins and their annotated locations for NP_001102337.2

Status: VALIDATED

Source sequence(s)

AI713913, BE116721, BQ210423, CB793692, CB814013, CK845516, CO573950, DY553859

UniProtKB/TrEMBL

A0A8I6ANJ2, A6KGU5, D4A0E8

Related

ENSRNOP00000016302.4, ENSRNOT00000016302.6

Conserved Domains (3) summary

pfam05185
Location:295 → 464

PRMT5; PRMT5 arginine-N-methyltransferase

pfam17285
Location:37 → 290

PRMT5_TIM; PRMT5 TIM barrel domain

pfam17286
Location:468 → 635

PRMT5_C; PRMT5 oligomerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

31938927..31948318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093546.2 → XP_038949474.1 protein arginine N-methyltransferase 5 isoform X1

UniProtKB/TrEMBL

A0A8I5ZP89

Related

ENSRNOP00000080060.1, ENSRNOT00000097219.2

Conserved Domains (3) summary

pfam05185
Location:189 → 358

PRMT5; PRMT5 arginine-N-methyltransferase

pfam17285
Location:1 → 184

PRMT5_TIM; PRMT5 TIM barrel domain

pfam17286
Location:362 → 529

PRMT5_C; PRMT5 oligomerization domain