Tysnd1 trypsin like peroxisomal matrix peptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tysnd1provided by RGD
Official Full Name: trypsin like peroxisomal matrix peptidase 1provided by RGD
Primary source: RGD:1307354
See related: EnsemblRapid:ENSRNOG00000024839 AllianceGenome:RGD:1307354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; protease binding activity; and serine-type endopeptidase activity. Predicted to be involved in protein processing and regulation of fatty acid beta-oxidation. Predicted to be active in peroxisome. Orthologous to human TYSND1 (trypsin like peroxisomal matrix peptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 183.4), Liver (RPKM 141.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30180878..30188239)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (29637942..29646492)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31313018..31318736)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tysnd1-mediated processing of the peroxisomal enzymes promotes their assembly into a supramolecular complex to enhance the rate of beta-oxidation.
Title: Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: peroxisomal leader peptide-processing protease

Names: trypsin domain containing 1

NP_001102402.1

EC 3.4.21.-

XP_038954828.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108932.1 → NP_001102402.1 peroxisomal leader peptide-processing protease

See identical proteins and their annotated locations for NP_001102402.1

Status: PROVISIONAL

Source sequence(s)

CH474016

UniProtKB/TrEMBL

B1H261, F7FC90

Related

ENSRNOP00000035866.2, ENSRNOT00000036719.4

Conserved Domains (1) summary

pfam13365
Location:358 → 497

Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30180878..30188239

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098900.2 → XP_038954828.1 peroxisomal leader peptide-processing protease isoform X1

UniProtKB/TrEMBL

A6K416

Conserved Domains (1) summary

cl21584
Location:358 → 429

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...