Rnf167 ring finger protein 167 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf167provided by RGD
Official Full Name: ring finger protein 167provided by RGD
Primary source: RGD:1305972
See related: EnsemblRapid:ENSRNOG00000003879 AllianceGenome:RGD:1305972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305972
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to leucine starvation; protein polyubiquitination; and regulation of TORC1 signaling. Predicted to be located in endosome. Predicted to be active in cytosol and endolysosome membrane. Orthologous to human RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 358.0), Spleen (RPKM 279.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55859254..55863546)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55360603..55364927)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57268331..57272667)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AV328608 (e-PCR)
- UniSTS:180240

RH136477 (e-PCR)
- UniSTS:210462

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in organelle localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endolysosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF167

Names: RING-type E3 ubiquitin transferase RNF167

NP_001008362.1

EC 2.3.2.27

XP_006246812.1

EC 2.3.2.27

XP_038942250.1

EC 2.3.2.27

XP_063125409.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008361.1 → NP_001008362.1 E3 ubiquitin-protein ligase RNF167 precursor

See identical proteins and their annotated locations for NP_001008362.1

Status: PROVISIONAL

Source sequence(s)

BC083670

UniProtKB/Swiss-Prot

Q5XIL0

UniProtKB/TrEMBL

A6HG77, A6HG78

Related

ENSRNOP00000005242.4, ENSRNOT00000005242.6

Conserved Domains (2) summary

cd02123
Location:20 → 170

PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

cd16797
Location:228 → 273

RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55859254..55863546

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246750.5 → XP_006246812.1 E3 ubiquitin-protein ligase RNF167 isoform X1

UniProtKB/TrEMBL

A0A8I6AG57

Related

ENSRNOP00000087224.1, ENSRNOT00000115572.2

Conserved Domains (2) summary

cd02123
Location:1 → 135

PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

cd16797
Location:193 → 238

RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
XM_039086322.2 → XP_038942250.1 E3 ubiquitin-protein ligase RNF167 isoform X2

UniProtKB/TrEMBL

A6HG79

Conserved Domains (3) summary

cd00162
Location:109 → 150

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

cl28883
Location:1 → 49

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

cl17238
Location:107 → 152

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_063269339.1 → XP_063125409.1 E3 ubiquitin-protein ligase RNF167 isoform X2

UniProtKB/TrEMBL

A6HG79