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    Klhl18 kelch-like family member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl18provided by RGD
    Official Full Name
    kelch-like family member 18provided by RGD
    Primary source
    RGD:1310570
    See related
    EnsemblRapid:ENSRNOG00000020880 AllianceGenome:RGD:1310570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310570
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of mitotic cell cycle phase transition; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 64.2), Kidney (RPKM 51.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl18 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119279081..119337850, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110400679..110459442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118668809..118737672, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein Neighboring gene kinesin family member 9 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene uncharacterized LOC108351781

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A. Moghe S, et al. Biol Open, 2012 Feb 15. PMID 23213400, Free PMC Article
    2. Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. Chaya T, et al. EMBO J, 2019 Dec 2. PMID 31696965, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 18
    Names
    kelch-like 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399324.1 → NP_001386253.1  kelch-like protein 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1M3S0
      Related
      ENSRNOP00000052988.6, ENSRNOT00000056141.7
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 552
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326 → 369
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    2. NM_001399325.1 → NP_001386254.1  kelch-like protein 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZLS4
      Related
      ENSRNOP00000078958.1, ENSRNOT00000109992.2
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:331 → 374
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119279081..119337850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265631.1 → XP_063121701.1  kelch-like protein 18 isoform X1

    2. XM_006244007.4 → XP_006244069.1  kelch-like protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006244069.1

      Conserved Domains (4) summary
      smart00612
      Location:277 → 323
      Kelch; Kelch domain
      sd00038
      Location:219 → 262
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:218 → 263
      Kelch_1; Kelch motif
      pfam07707
      Location:28 → 130
      BACK; BTB And C-terminal Kelch

    3. XM_039082647.2 → XP_038938575.1  kelch-like protein 18 isoform X3

      Conserved Domains (2) summary
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    4. XM_039082646.2 → XP_038938574.1  kelch-like protein 18 isoform X2

      Conserved Domains (5) summary
      smart00612
      Location:289 → 341
      Kelch; Kelch domain
      sd00038
      Location:282 → 327
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
      pfam01344
      Location:330 → 375
      Kelch_1; Kelch motif

    RNA

    1. XR_005488466.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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