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    Sgsm2 small G protein signaling modulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgsm2provided by RGD
    Official Full Name
    small G protein signaling modulator 2provided by RGD
    Primary source
    RGD:1306957
    See related
    EnsemblRapid:ENSRNOG00000027194 AllianceGenome:RGD:1306957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rutbc1
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in late endosome to Golgi transport and positive regulation of GTPase activity. Predicted to be located in melanosome. Orthologous to human SGSM2 (small G protein signaling modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 85.8), Adrenal (RPKM 84.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgsm2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60216556..60258199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59718180..59759822, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61703837..61745110, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene MAX network transcriptional repressor Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene TSR1, ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. Nottingham RM, et al. J Biol Chem, 2011 Sep 23. PMID 21808068, Free PMC Article
    2. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. Marubashi S, et al. J Biol Chem, 2016 Jan 15. PMID 26620560, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small G protein signaling modulator 2
    Names
    RUN and TBC1 domain containing 1
    NP_001100490.1
    XP_006246802.1
    XP_006246803.1
    XP_038941941.1
    XP_063125131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107020.1 → NP_001100490.1  small G protein signaling modulator 2

      See identical proteins and their annotated locations for NP_001100490.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A0G2K6Y4, A6HGN6, D3ZW66
      Related
      ENSRNOP00000032080.4, ENSRNOT00000034298.8
      Conserved Domains (3) summary
      smart00164
      Location:793 → 961
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:256 → 424
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:42 → 189
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60216556..60258199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086013.2 → XP_038941941.1  small G protein signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6Y4
      Conserved Domains (3) summary
      smart00164
      Location:815 → 983
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:233 → 401
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:19 → 162
      RUN; RUN domain

    2. XM_006246740.4 → XP_006246802.1  small G protein signaling modulator 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6Y4, A0A0U1RS33
      Related
      ENSRNOP00000075916.1, ENSRNOT00000092314.3
      Conserved Domains (3) summary
      smart00164
      Location:838 → 1006
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:256 → 424
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:42 → 189
      RUN; RUN domain

    3. XM_006246741.5 → XP_006246803.1  small G protein signaling modulator 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6Y4
      Conserved Domains (3) summary
      smart00164
      Location:771 → 939
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:189 → 357
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:1 → 122
      RUN; RUN domain

    4. XM_063269061.1 → XP_063125131.1  small G protein signaling modulator 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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