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    Nexmif neurite extension and migration factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nexmifprovided by RGD
    Official Full Name
    neurite extension and migration factorprovided by RGD
    Primary source
    RGD:1561931
    See related
    EnsemblRapid:ENSRNOG00000021589 AllianceGenome:RGD:1561931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Xpn; KIDLIA; KIAA2022; RGD1561931
    Summary
    Involved in negative regulation of cell adhesion and negative regulation of neuron migration. Predicted to be located in cytosol; midbody; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 98. Orthologous to human NEXMIF (neurite extension and migration factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 121.6), Brain (RPKM 67.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nexmif in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (73153786..73284943, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (69088076..69219253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (74943440..75053559, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene splicing factor 3A subunit 2, pseudogene 2 Neighboring gene microRNA 672 Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene uracil phosphoribosyltransferase homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth. Van Maldergem L, et al. Hum Mol Genet, 2013 Aug 15. PMID 23615299, Free PMC Article
    2. XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration. Magome T, et al. Neurochem Int, 2013 Nov. PMID 24071057
    3. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling. Gilbert J, et al. eNeuro, 2016 Sep-Oct. PMID 27822498, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin.
      Title: The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling.
    2. Result showed that siRNA-mediated KIAA2022 knockdown resulted in marked impairment in neurite outgrowth including both the dendrites and the axons, suggesting a major role for KIAA2022 in neuron development and brain function.
      Title: Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurite extension and migration factor
    Names
    XLMR protein related to neurite extension

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313815.1 → NP_001300744.1  neurite extension and migration factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      D3ZGX1
      Related
      ENSRNOP00000036176.6, ENSRNOT00000035653.9
      Conserved Domains (1) summary
      pfam15735
      Location:291 → 691
      DUF4683; Domain of unknown function (DUF4683)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      73153786..73284943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099592.2 → XP_038955520.1  neurite extension and migration factor isoform X1

      UniProtKB/Swiss-Prot
      D3ZGX1
      Conserved Domains (1) summary
      pfam15735
      Location:291 → 691
      DUF4683; Domain of unknown function (DUF4683)

    2. XM_039099590.2 → XP_038955518.1  neurite extension and migration factor isoform X1

      UniProtKB/Swiss-Prot
      D3ZGX1
      Conserved Domains (1) summary
      pfam15735
      Location:291 → 691
      DUF4683; Domain of unknown function (DUF4683)

    3. XM_039099591.2 → XP_038955519.1  neurite extension and migration factor isoform X1

      UniProtKB/Swiss-Prot
      D3ZGX1
      Conserved Domains (1) summary
      pfam15735
      Location:291 → 691
      DUF4683; Domain of unknown function (DUF4683)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZGX1.1 GenPept UniProtKB/Swiss-Prot:D3ZGX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.