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    Slc22a23 solute carrier family 22, member 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64559, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a23provided by RGD
    Official Full Name
    solute carrier family 22, member 23provided by RGD
    Primary source
    RGD:620302
    See related
    EnsemblRapid:ENSRNOG00000017210 AllianceGenome:RGD:620302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nritp
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 286.6), Kidney (RPKM 279.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc22a23 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (30749445..30915139)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30544106..30709790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (31236015..31403685)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50, member B Neighboring gene PX domain containing 1 Neighboring gene uncharacterized LOC134482704 Neighboring gene uncharacterized LOC120097753 Neighboring gene proteasome assembly chaperone 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume. Uchimura Y, et al. PLoS One, 2024. PMID 39197039, Free PMC Article
    2. Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23. Bennett KM, et al. Mol Cell Biochem, 2011 Jun. PMID 21359964, Free PMC Article
    3. Expression of the GDNF family members and their receptors in the mature rat cochlea. Stöver T, et al. Brain Res Mol Brain Res, 2000 Mar 10. PMID 10719212
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
      Title: Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
    2. These novel family members have a nonconserved amino terminus, relative to other organic cation transporters, that may preclude typical SLC22 transport function
      Title: Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 23
    Names
    ion transporter protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022624.1 → NP_072146.1  solute carrier family 22 member 23

      See identical proteins and their annotated locations for NP_072146.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q9QZG1
      UniProtKB/TrEMBL
      A0A8I6AGL6
      Related
      ENSRNOP00000023149.5, ENSRNOT00000023149.7
      Conserved Domains (1) summary
      cd17444
      Location:187 → 608
      MFS_SLC22A23; Solute carrier family 22, member 23 of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      30749445..30915139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253845.5 → XP_006253907.1  solute carrier family 22 member 23 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABT6, A0A8I6AGL6
      Related
      ENSRNOP00000090447.1, ENSRNOT00000099248.2
      Conserved Domains (2) summary
      cd06174
      Location:230 → 359
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:98 → 623
      2A0119; cation transport protein

    2. XM_039096053.2 → XP_038951981.1  solute carrier family 22 member 23 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:134 → 493
      MFS; Major Facilitator Superfamily

    3. XM_063276724.1 → XP_063132794.1  solute carrier family 22 member 23 isoform X3

    4. XM_063276725.1 → XP_063132795.1  solute carrier family 22 member 23 isoform X4

    5. XM_063276726.1 → XP_063132796.1  solute carrier family 22 member 23 isoform X5

    6. XM_063276727.1 → XP_063132797.1  solute carrier family 22 member 23 isoform X6

    RNA

    1. XR_010058929.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZG1.2 GenPept UniProtKB/Swiss-Prot:Q9QZG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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