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    B3galnt2 beta-1,3-N-acetylgalactosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291212, updated on 4-Jan-2025

    Summary

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    Official Symbol
    B3galnt2provided by RGD
    Official Full Name
    beta-1,3-N-acetylgalactosaminyltransferase 2provided by RGD
    Primary source
    RGD:1306946
    See related
    EnsemblRapid:ENSRNOG00000016855 AllianceGenome:RGD:1306946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306946
    Summary
    Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A11. Orthologous to human B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 219.4), Heart (RPKM 174.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3galnt2 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (56030409..56072952, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (51334921..51377469, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (54027859..54070399, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 4B Neighboring gene geranylgeranyl diphosphate synthase 1 Neighboring gene tubulin folding cofactor E Neighboring gene ribosomal protein S19 like 4 Neighboring gene uncharacterized LOC134482723 Neighboring gene kinesin family member 5B Neighboring gene Rho GTPase activating protein 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in B3GALNT2 cause congenital muscular dystrophy and hypoglycosylation of α-dystroglycan. Stevens E, et al. Am J Hum Genet, 2013 Mar 7. PMID 23453667, Free PMC Article
    2. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
    Names
    UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
    NP_001138323.1
    XP_006254069.1
    XP_006254070.1
    XP_008769923.1
    XP_038951453.1
    XP_063132272.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144851.2 → NP_001138323.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

      See identical proteins and their annotated locations for NP_001138323.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K550, A6K9D8, D3Z9C4
      Related
      ENSRNOP00000022924.5, ENSRNOT00000022924.8
      Conserved Domains (1) summary
      cl21608
      Location:309 → 459
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      56030409..56072952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254007.5 → XP_006254069.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K550, A0A8I6GEP1
      Related
      ENSRNOP00000086193.1, ENSRNOT00000105211.2
      Conserved Domains (1) summary
      cl21608
      Location:277 → 427
      Galactosyl_T; Galactosyltransferase

    2. XM_008771701.4 → XP_008769923.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K550
      Conserved Domains (1) summary
      cl21608
      Location:308 → 458
      Galactosyl_T; Galactosyltransferase

    3. XM_063276202.1 → XP_063132272.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K550

    4. XM_006254008.4 → XP_006254070.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X3

      See identical proteins and their annotated locations for XP_006254070.1

      UniProtKB/TrEMBL
      A0A0G2K550, A0A8I6GHC5
      Conserved Domains (1) summary
      cl21608
      Location:261 → 411
      Galactosyl_T; Galactosyltransferase

    5. XM_039095525.2 → XP_038951453.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K550, A0A8I6GHC5
      Related
      ENSRNOP00000088702.1, ENSRNOT00000117768.2
      Conserved Domains (1) summary
      cl21608
      Location:261 → 411
      Galactosyl_T; Galactosyltransferase

    RNA

    1. XR_361036.5 RNA Sequence

    2. XR_005495256.2 RNA Sequence

    3. XR_010058837.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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