U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 65099, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irak1bp1provided by MGI
    Official Full Name
    interleukin-1 receptor-associated kinase 1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1929475
    See related
    Ensembl:ENSMUSG00000032251 AllianceGenome:MGI:1929475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aabp3; Aip70; Simpl; 4921528N06Rik
    Summary
    Enables signaling adaptor activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 11.5), CNS E18 (RPKM 10.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Irak1bp1 in Genome Data Viewer
    Location:
    9 E2; 9 45.16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (82711859..82729741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (82829806..82847688)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24778 Neighboring gene STARR-seq mESC enhancer starr_24779 Neighboring gene predicted gene, 24393 Neighboring gene STARR-seq mESC enhancer starr_24780 Neighboring gene predicted gene, 35690 Neighboring gene STARR-seq mESC enhancer starr_24781 Neighboring gene STARR-positive B cell enhancer ABC_E10566 Neighboring gene predicted gene, 38553 Neighboring gene STARR-positive B cell enhancer mm9_chr9:82782399-82782699 Neighboring gene STARR-positive B cell enhancer ABC_E10568 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene predicted gene, 39382

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase 1-binding protein 1
    Names
    Acta binding protein 3
    Acta-binding protein 70
    IRAK1-binding protein 1
    Plk-interacting protein
    signaling molecule that associates with the mouse pelle-like kinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168240.1NP_001161712.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001161712.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK014712, AK045436, BY719456
      Consensus CDS
      CCDS52871.1
      UniProtKB/TrEMBL
      G5E885
      Related
      ENSMUSP00000034783.5, ENSMUST00000034783.6
      Conserved Domains (1) summary
      pfam04402
      Location:55174
      SIMPL; Protein of unknown function (DUF541)
    2. NM_022986.4NP_075362.3  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_075362.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK045436, BY719456
      Consensus CDS
      CCDS23372.1
      UniProtKB/Swiss-Prot
      Q8BT82, Q8C645, Q9CRM0, Q9CV21, Q9CX27, Q9ESJ7, Q9JK12
      Related
      ENSMUSP00000108871.3, ENSMUST00000113245.9
      Conserved Domains (1) summary
      pfam04402
      Location:55196
      SIMPL; Protein of unknown function (DUF541)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      82711859..82729741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)