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    Ube2e2 ubiquitin-conjugating enzyme E2E 2 [ Mus musculus (house mouse) ]

    Gene ID: 218793, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ube2e2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2E 2provided by MGI
    Primary source
    MGI:MGI:2384997
    See related
    Ensembl:ENSMUSG00000058317 AllianceGenome:MGI:2384997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in protein modification by small protein conjugation. Predicted to act upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including eye; genitourinary system; gut; integumental system; and nervous system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E2 (ubiquitin conjugating enzyme E2 E2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.9), cortex adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2e2 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (3575429..3896133)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18573563..18894284, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene clusterin like 1, pseudogene 2 Neighboring gene kinesin family member 2C pseudogene Neighboring gene STARR-seq mESC enhancer starr_36061 Neighboring gene STARR-seq mESC enhancer starr_36060 Neighboring gene aurora kinase A pseudogene Neighboring gene predicted gene, 22499 Neighboring gene STARR-seq mESC enhancer starr_36059 Neighboring gene STARR-seq mESC enhancer starr_36058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:19498168-19498444 Neighboring gene STARR-seq mESC enhancer starr_36056 Neighboring gene STARR-seq mESC enhancer starr_36055 Neighboring gene STARR-seq mESC enhancer starr_36054 Neighboring gene predicted gene, 32587 Neighboring gene vacuolar protein sorting 4b pseudogene Neighboring gene farnesyl diphosphate farnesyl transferase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC28917

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ISG15 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ISG15 transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ISG15 transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ISG15-protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ISG15-protein conjugation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 E2
    Names
    E2 ubiquitin-conjugating enzyme E2
    TBC1 domain family, member 12
    ubiquitin carrier protein E2
    ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
    ubiquitin-protein ligase E2
    NP_001347256.1
    NP_001347257.1
    NP_659088.1
    XP_006518075.1
    XP_017171445.1
    XP_017171446.1
    XP_017171447.1
    XP_017171448.1
    XP_017171449.1
    XP_036014440.1
    XP_036014441.1
    XP_036014442.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360327.1NP_001347256.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118006, AW495303, BY290283, CF732742, DN172861
      Consensus CDS
      CCDS26838.1
      UniProtKB/Swiss-Prot
      Q91W82
      Related
      ENSMUSP00000075495.4, ENSMUST00000076133.10
      Conserved Domains (1) summary
      pfam00179
      Location:59196
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001360328.1NP_001347257.1  ubiquitin-conjugating enzyme E2 E2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW495303, BY250357, CF732742, CX208846
      UniProtKB/TrEMBL
      D3YXD1
      Related
      ENSMUSP00000118321.2, ENSMUST00000151926.8
      Conserved Domains (1) summary
      pfam00179
      Location:83220
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_144839.2NP_659088.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

      See identical proteins and their annotated locations for NP_659088.1

      Status: VALIDATED

      Source sequence(s)
      AC118006, AW495303, BY752670, CF732742, DN172861
      Consensus CDS
      CCDS26838.1
      UniProtKB/Swiss-Prot
      Q91W82
      Related
      ENSMUSP00000115738.2, ENSMUST00000150727.8
      Conserved Domains (1) summary
      pfam00179
      Location:59196
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      3575429..3896133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158547.1XP_036014440.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

      Conserved Domains (1) summary
      pfam00179
      Location:59202
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_017315958.3XP_017171447.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

      Conserved Domains (1) summary
      pfam00179
      Location:59210
      UQ_con; Ubiquitin-conjugating enzyme
    3. XM_036158549.1XP_036014442.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

      Conserved Domains (1) summary
      pfam00179
      Location:48179
      UQ_con; Ubiquitin-conjugating enzyme
    4. XM_006518012.4XP_006518075.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

      Conserved Domains (1) summary
      pfam00179
      Location:59202
      UQ_con; Ubiquitin-conjugating enzyme
    5. XM_017315960.3XP_017171449.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

      Conserved Domains (1) summary
      pfam00179
      Location:59210
      UQ_con; Ubiquitin-conjugating enzyme
    6. XM_036158548.1XP_036014441.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

      Conserved Domains (1) summary
      pfam00179
      Location:48179
      UQ_con; Ubiquitin-conjugating enzyme
    7. XM_017315957.3XP_017171446.1  ubiquitin-conjugating enzyme E2 E2 isoform X2

      Conserved Domains (1) summary
      pfam00179
      Location:83226
      UQ_con; Ubiquitin-conjugating enzyme
    8. XM_017315956.3XP_017171445.1  ubiquitin-conjugating enzyme E2 E2 isoform X1

      Conserved Domains (1) summary
      pfam00179
      Location:83234
      UQ_con; Ubiquitin-conjugating enzyme
    9. XM_017315959.3XP_017171448.1  ubiquitin-conjugating enzyme E2 E2 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:72203
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. XR_004938379.1 RNA Sequence