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    Ifit1 interferon-induced protein with tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 15957, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ifit1provided by MGI
    Official Full Name
    interferon-induced protein with tetratricopeptide repeats 1provided by MGI
    Primary source
    MGI:MGI:99450
    See related
    Ensembl:ENSMUSG00000034459 AllianceGenome:MGI:99450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P56; ISG56; Ifi56; GARG-16; IFI-56K
    Summary
    Predicted to enable RNA binding activity. Involved in response to virus. Acts upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 7.6), liver E18 (RPKM 5.2) and 23 other tissues See more
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    Genomic context

    See Ifit1 in Genome Data Viewer
    Location:
    19 C1; 19 29.78 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34618289..34627409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34640889..34650009)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18425

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 1
    Names
    glucocorticoid-attenuated response gene 16 protein
    interferon-induced 56 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008331.4NP_032357.2  interferon-induced protein with tetratricopeptide repeats 1

      See identical proteins and their annotated locations for NP_032357.2

      Status: VALIDATED

      Source sequence(s)
      AC016791
      Consensus CDS
      CCDS29766.1
      UniProtKB/Swiss-Prot
      Q64282, Q99L77
      UniProtKB/TrEMBL
      Q3U5K8, Q3U5N2, Q3U7A2, Q3UNG3, Q8BN43
      Related
      ENSMUSP00000099888.4, ENSMUST00000102824.4
      Conserved Domains (4) summary
      TIGR02521
      Location:194354
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      sd00006
      Location:242270
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54124
      TPR_12; Tetratricopeptide repeat
      pfam13432
      Location:145208
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34618289..34627409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)