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    Pde2a phosphodiesterase 2A, cGMP-stimulated [ Mus musculus (house mouse) ]

    Gene ID: 207728, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pde2aprovided by MGI
    Official Full Name
    phosphodiesterase 2A, cGMP-stimulatedprovided by MGI
    Primary source
    MGI:MGI:2446107
    See related
    Ensembl:ENSMUSG00000030653 Ensembl:ENSMUSG00000110195 AllianceGenome:MGI:2446107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cGSPDE; CGS-PDE
    Summary
    Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; intracellular signaling cassette; and negative regulation of intracellular signal transduction. Acts upstream of or within circulatory system development and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pde2a in Genome Data Viewer
    Location:
    7 E2; 7 54.57 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101070905..101162026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101421691..101512829)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene STARR-seq mESC enhancer starr_19692 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E4957 Neighboring gene STARR-positive B cell enhancer ABC_E1740 Neighboring gene microRNA 139 Neighboring gene predicted gene, 35363 Neighboring gene STARR-positive B cell enhancer ABC_E6576 Neighboring gene STARR-seq mESC enhancer starr_19694 Neighboring gene predicted gene, 19765 Neighboring gene ADP-ribosyltransferase 2a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102210

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GAF domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cGMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cGMP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cGMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cGMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cGMP-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cGMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to macrophage colony-stimulating factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hippocampal mossy fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cGMP-dependent 3',5'-cyclic phosphodiesterase
    Names
    cyclic GMP-stimulated phosphodiesterase
    NP_001008548.1
    NP_001137320.1
    NP_001137321.1
    NP_001230686.1
    NP_001230687.1
    NP_001407472.1
    NP_001407473.1
    NP_001407474.1
    NP_001407475.1
    NP_001407477.1
    NP_001407478.1
    NP_001407479.1
    XP_006507586.1
    XP_006507587.1
    XP_006507589.1
    XP_006507592.1
    XP_030098167.1
    XP_036008744.1
    XP_036008745.1
    XP_036008746.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008548.5NP_001008548.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3

      See identical proteins and their annotated locations for NP_001008548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A3 (see, PMID:19632989) is shorter, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS40043.1
      UniProtKB/TrEMBL
      Q3TYK5, Q5PR72
      Related
      ENSMUSP00000147847.2, ENSMUST00000211368.2
      Conserved Domains (2) summary
      smart00065
      Location:404553
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:650883
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001143848.3NP_001137320.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6

      See identical proteins and their annotated locations for NP_001137320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (6).
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS52330.1
      UniProtKB/Swiss-Prot
      Q3TCR8, Q3TXZ6, Q8K2U1, Q922S4
      UniProtKB/TrEMBL
      Q3TYK5
      Related
      ENSMUSP00000131553.3, ENSMUST00000163751.10
      Conserved Domains (2) summary
      smart00065
      Location:408557
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:654884
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. NM_001143849.3NP_001137321.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2

      See identical proteins and their annotated locations for NP_001137321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, has a distinct 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A2 (see PMID:21724846) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TD37
      Conserved Domains (2) summary
      smart00065
      Location:397546
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:643876
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. NM_001243757.2NP_001230686.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

      See identical proteins and their annotated locations for NP_001230686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform, PDE2A1 (see PMID:19632989) is shorter and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      F7D3W5
      Related
      ENSMUSP00000081956.9, ENSMUST00000084894.15
      Conserved Domains (2) summary
      smart00065
      Location:385534
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:631864
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. NM_001243758.2NP_001230687.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS85351.1
      UniProtKB/TrEMBL
      A0A1B0GRJ9, Q3TYK5
      Related
      ENSMUSP00000147553.2, ENSMUST00000209537.2
      Conserved Domains (2) summary
      smart00065
      Location:414563
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:660893
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. NM_001420543.1NP_001407472.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    7. NM_001420544.1NP_001407473.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    8. NM_001420545.1NP_001407474.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    9. NM_001420546.1NP_001407475.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    10. NM_001420548.1NP_001407477.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    11. NM_001420549.1NP_001407478.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
    12. NM_001420550.1NP_001407479.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609

    RNA

    1. NR_152193.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129079, AC129609
      Related
      ENSMUST00000210364.2
    2. NR_152194.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129079, AC129609

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101070905..101162026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152852.1XP_036008745.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_006507524.3XP_006507587.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:418567
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:664897
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. XM_006507526.3XP_006507589.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      See identical proteins and their annotated locations for XP_006507589.1

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_036152853.1XP_036008746.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:386535
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:632865
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. XM_036152851.1XP_036008744.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. XM_030242307.2XP_030098167.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:385534
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:631864
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    7. XM_006507529.3XP_006507592.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

      See identical proteins and their annotated locations for XP_006507592.1

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:268417
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:514747
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    8. XM_006507523.3XP_006507586.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:422571
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:668901
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase