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    Scpep1 serine carboxypeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74617, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scpep1provided by MGI
    Official Full Name
    serine carboxypeptidase 1provided by MGI
    Primary source
    MGI:MGI:1921867
    See related
    Ensembl:ENSMUSG00000000278 AllianceGenome:MGI:1921867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Risc; 2410018F01Rik; 4833411K15Rik
    Summary
    Enables serine-type carboxypeptidase activity. Involved in negative regulation of blood pressure. Acts upstream of or within blood vessel diameter maintenance. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and musculature. Orthologous to human SCPEP1 (serine carboxypeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 73.9), bladder adult (RPKM 35.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Scpep1 in Genome Data Viewer
    Location:
    11 C; 11 54.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88814846..88846268, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88924020..88955442, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 1 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene predicted gene, 23507 Neighboring gene STARR-seq mESC enhancer starr_30370 Neighboring gene STARR-seq mESC enhancer starr_30374 Neighboring gene STARR-positive B cell enhancer ABC_E3993 Neighboring gene STARR-seq mESC enhancer starr_30376 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30377 Neighboring gene STARR-positive B cell enhancer ABC_E10705 Neighboring gene elongin B-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel diameter maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    retinoid-inducible serine carboxypeptidase
    Names
    retinoid-inducible serine caroboxypeptidase
    retinoid-inducible serine caroboxypetidase
    serine caroboxypeptidase 1
    NP_083299.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029023.3NP_083299.3  retinoid-inducible serine carboxypeptidase precursor

      See identical proteins and their annotated locations for NP_083299.3

      Status: VALIDATED

      Source sequence(s)
      AK014680, BX518946
      Consensus CDS
      CCDS25230.1
      UniProtKB/Swiss-Prot
      Q920A5, Q9D625
      UniProtKB/TrEMBL
      Q99J29
      Related
      ENSMUSP00000000287.9, ENSMUST00000000287.9
      Conserved Domains (1) summary
      pfam00450
      Location:34451
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      88814846..88846268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)