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    Crebbp CREB binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12914, updated on 4-Jan-2025

    Summary

    Official Symbol
    Crebbpprovided by MGI
    Official Full Name
    CREB binding proteinprovided by MGI
    Primary source
    MGI:MGI:1098280
    See related
    Ensembl:ENSMUSG00000022521 AllianceGenome:MGI:1098280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CBP; KAT3A; CBP/p300; p300/CBP
    Summary
    Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including embryo ectoderm; eye; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 14.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Crebbp in Genome Data Viewer
    Location:
    16 A1; 16 2.4 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3899198..4031864, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4081334..4213957, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_39914 Neighboring gene deoxyribonuclease I Neighboring gene TNF receptor-associated protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4077725-4077912 Neighboring gene STARR-seq mESC enhancer starr_39921 Neighboring gene RIKEN cDNA 4930455F16 gene Neighboring gene ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 63
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables MRF binding  
    enables MRF binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SMAD binding  
    enables TFIIB-class transcription factor binding PubMed 
    enables acetyltransferase activity  
    enables acetyltransferase activity  
    enables cAMP response element binding protein binding PubMed 
    enables chromatin DNA binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables damaged DNA binding  
    enables damaged DNA binding  
    enables disordered domain specific binding PubMed 
    enables histone H2AK5 acetyltransferase activity  
    enables histone H2AK9 acetyltransferase activity  
    enables histone H2BK12 acetyltransferase activity  
    enables histone H2BK5 acetyltransferase activity  
    enables histone H3K122 acetyltransferase activity  
    enables histone H3K14 acetyltransferase activity  
    enables histone H3K18 acetyltransferase activity  
    enables histone H3K18 acetyltransferase activity  
    enables histone H3K23 acetyltransferase activity  
    enables histone H3K27 acetyltransferase activity  
    enables histone H3K27 acetyltransferase activity  
    enables histone H3K36 acetyltransferase activity  
    enables histone H3K4 acetyltransferase activity  
    enables histone H3K56 acetyltransferase activity  
    enables histone H3K9 acetyltransferase activity  
    enables histone H4K12 acetyltransferase activity  
    enables histone H4K16 acetyltransferase activity  
    enables histone H4K5 acetyltransferase activity  
    enables histone H4K8 acetyltransferase activity  
    enables histone acetyltransferase activity  
    enables histone acetyltransferase activity PubMed 
    enables histone acetyltransferase activity  
    enables histone acetyltransferase activity  
    enables histone acetyltransferase activity  
    enables histone lactyltransferase (CoA-dependent) activity  
    enables molecular adaptor activity PubMed 
    enables p53 binding  
    enables peptide lactyltransferase (CoA-dependent) activity  
    enables peptide lactyltransferase (CoA-dependent) activity  
    enables peptide-lysine-N-acetyltransferase activity  
    enables peptide-lysine-N-acetyltransferase activity  
    enables peroxisome proliferator activated receptor binding  
    contributes_to protein binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein-containing complex binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator binding  
    enables transcription corepressor activity  
    enables zinc ion binding PubMed 
    Items 1 - 25 of 63
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation  
    involved_in N-terminal peptidyl-lysine acetylation  
    involved_in behavioral response to cocaine  
    involved_in canonical NF-kappaB signal transduction  
    involved_in cellular response to UV  
    involved_in cellular response to UV  
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus PubMed 
    involved_in cellular response to nutrient levels  
    involved_in cellular response to virus PubMed 
    involved_in chromatin remodeling  
    involved_in face morphogenesis PubMed 
    acts_upstream_of_or_within germ-line stem cell population maintenance PubMed 
    involved_in long-term memory  
    involved_in negative regulation of interferon-beta production PubMed 
    involved_in negative regulation of transcription by RNA polymerase I  
    involved_in negative regulation of transcription by RNA polymerase I  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of viral process PubMed 
    acts_upstream_of_or_within positive regulation of CREB transcription factor activity PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of cell adhesion molecule production  
    involved_in positive regulation of dendritic spine development  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in protein acetylation  
    involved_in protein destabilization  
    involved_in protein destabilization  
    involved_in protein modification process  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in rhythmic process  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in PML body PubMed 
    part_of RNA polymerase II transcription regulator complex PubMed 
    located_in chromatin PubMed 
    located_in chromatin  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    part_of histone acetyltransferase complex  
    part_of histone acetyltransferase complex PubMed 
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of outer kinetochore PubMed 
    part_of protein-containing complex PubMed 
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    histone lysine acetyltransferase CREBBP
    Names
    protein lactyltransferas CREBBP
    protein-lysine acetyltransferase CREBBP
    NP_001020603.1
    XP_006521814.1
    XP_006521815.1
    XP_006521816.1
    XP_006521817.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025432.1NP_001020603.1  histone lysine acetyltransferase CREBBP

      See identical proteins and their annotated locations for NP_001020603.1

      Status: VALIDATED

      Source sequence(s)
      BC010297, BC072594, BU705617, CAAA01026247
      Consensus CDS
      CCDS27915.1
      UniProtKB/Swiss-Prot
      E9QPH4, P45481
      UniProtKB/TrEMBL
      F8VPR5
      Related
      ENSMUSP00000023165.7, ENSMUST00000023165.9
      Conserved Domains (10) summary
      cd05495
      Location:10881195
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17671845
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      COG5076
      Location:9421194
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17061746
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12071279
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12811312
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13431650
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20352112
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3899198..4031864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521754.5XP_006521817.1  histone lysine acetyltransferase CREBBP isoform X4

      UniProtKB/Swiss-Prot
      E9QPH4, P45481
      UniProtKB/TrEMBL
      A0A0U1RQB6
      Related
      ENSMUSP00000146330.2, ENSMUST00000205765.2
      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17291807
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:649999
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9041156
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:16681708
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691241
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12431274
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19232374
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362404
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548628
      KIX; KIX domain
      pfam08214
      Location:13051516
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19972077
      Creb_binding; Creb binding
    2. XM_006521753.5XP_006521816.1  histone lysine acetyltransferase CREBBP isoform X3

      UniProtKB/Swiss-Prot
      E9QPH4, P45481
      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17391817
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:649999
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9041156
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:16781718
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691251
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12531284
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19332384
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362404
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548628
      KIX; KIX domain
      pfam08214
      Location:13151526
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20072087
      Creb_binding; Creb binding
    3. XM_006521751.5XP_006521814.1  histone lysine acetyltransferase CREBBP isoform X1

      UniProtKB/Swiss-Prot
      E9QPH4, P45481
      Conserved Domains (12) summary
      cd05495
      Location:10881195
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17771855
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:6871037
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9421194
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17161756
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12071289
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12911322
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19712422
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13531564
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20452125
      Creb_binding; Creb binding
    4. XM_006521752.4XP_006521815.1  histone lysine acetyltransferase CREBBP isoform X2

      UniProtKB/Swiss-Prot
      E9QPH4, P45481
      Conserved Domains (12) summary
      cd05495
      Location:10831190
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17721850
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:6801032
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9371189
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17111751
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12021284
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12861317
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19662417
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13481559
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20402120
      Creb_binding; Creb binding
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