Colq collagen like tail subunit of asymmetric acetylcholinesterase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Colqprovided by RGD
Official Full Name: collagen like tail subunit of asymmetric acetylcholinesteraseprovided by RGD
Primary source: RGD:2377
See related: EnsemblRapid:ENSRNOG00000019615 AllianceGenome:RGD:2377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables heparin binding activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within establishment of protein localization to membrane; regulation of synaptic assembly at neuromuscular junction; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be located in neuromuscular junction and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Orthologous to human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 47.8), Thymus (RPKM 19.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6738251..6830492, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6731850..6824973, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7626380..7681621, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extensive neural suppression of the extrajunctional ColQ expression in regenerating fast muscles during maturation is a very slow process requiring 30-60 days.
Title: Suppression of collagen Q expression in the extrajunctional regions of rat fast muscles is encoded in their stem cells (satellite cells).
differential distribution of P-CREB in fast-and slow-twitch muscles might support the crucial role of cAMP-dependent signaling in controlling the synapse-specific expression of ColQ-1a in fast-twitch muscles
Title: Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction.
AChE, BChE and PRiMA mRNA level modifications found in the absence of ColQ cannot compensate for the physiological defects observed at the ColQ-deficient neuromuscular junction.
Title: Cholinesterases regulation in the absence of ColQ.
extrajunctional levels of ColQ mRNA in non-innervated regenerating fast and slow muscles
Title: The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat muscles.
Extrajunctional collagen Q expression in fast muscles is independent of muscle activation and is partly nerve-dependent.
Title: Neural regulation of acetylcholinesterase-associated collagen Q in rat skeletal muscles.
In addition to its structural role, ColQ has important regulatory functions at the synapse by controlling acetylcholine receptor clustering through its interaction with MuSK.
Title: ColQ controls postsynaptic differentiation at the neuromuscular junction.
Acetylcholinesterase associates differently with its anchoring proteins ColQ and PRiMA
Title: Acetylcholinesterase associates differently with its anchoring proteins ColQ and PRiMA.
Two heparin-binding domains with different properties that may have non-redundant functions are described; may coordinate acetylcholinesterase positioning within the the neuromuscular junction basal lamina.
Title: Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase.

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General gene information

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Markers

RH137426 (e-PCR)
- UniSTS:219514

AI228720 (e-PCR)
- UniSTS:250580

D16Got91 (e-PCR)
- UniSTS:113911

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic assembly at neuromuscular junction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle acetylcholine-gated channel clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	TAS Traceable Author Statement more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetylcholinesterase collagenic tail peptide

Names: AChE Q subunit; acetylcholinesterase-associated collagen; collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019274.3 → NP_062147.2 acetylcholinesterase collagenic tail peptide precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

O35167

UniProtKB/TrEMBL

A6KFY6, F1M6X2

Related

ENSRNOP00000026550.5, ENSRNOT00000026550.7

Conserved Domains (2) summary

TIGR02232
Location:375 → 399

myxo_disulf_rpt; Myxococcus cysteine-rich repeat

pfam01391
Location:161 → 216

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

6738251..6830492 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094440.2 → XP_038950368.1 acetylcholinesterase collagenic tail peptide isoform X3

Conserved Domains (2) summary

pfam13948
Location:323 → 348

DUF4215; Domain of unknown function (DUF4215)

pfam01391
Location:107 → 162

Collagen; Collagen triple helix repeat (20 copies)
XM_039094438.2 → XP_038950366.1 acetylcholinesterase collagenic tail peptide isoform X1

UniProtKB/Swiss-Prot

O35167

Conserved Domains (2) summary

TIGR02232
Location:372 → 396

myxo_disulf_rpt; Myxococcus cysteine-rich repeat

pfam01391
Location:158 → 213

Collagen; Collagen triple helix repeat (20 copies)
XM_039094439.2 → XP_038950367.1 acetylcholinesterase collagenic tail peptide isoform X2

UniProtKB/Swiss-Prot

O35167

UniProtKB/TrEMBL

A0A8I6GM12

Related

ENSRNOP00000097353.1, ENSRNOT00000116928.2

Conserved Domains (2) summary

TIGR02232
Location:367 → 391

myxo_disulf_rpt; Myxococcus cysteine-rich repeat

pfam01391
Location:153 → 208

Collagen; Collagen triple helix repeat (20 copies)
XM_063275284.1 → XP_063131354.1 acetylcholinesterase collagenic tail peptide isoform X3
XM_063275285.1 → XP_063131355.1 acetylcholinesterase collagenic tail peptide isoform X4