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    Selenop selenoprotein P [ Mus musculus (house mouse) ]

    Gene ID: 20363, updated on 9-Dec-2024

    Summary

    Official Symbol
    Selenopprovided by MGI
    Official Full Name
    selenoprotein Pprovided by MGI
    Primary source
    MGI:MGI:894288
    See related
    Ensembl:ENSMUSG00000064373 AllianceGenome:MGI:894288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Se-P; selp; Sepp1; D15Ucla1
    Summary
    This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]
    Expression
    Broad expression in liver E18 (RPKM 1163.6), liver adult (RPKM 814.0) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Selenop in Genome Data Viewer
    Location:
    15 A1; 15 1.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (3300249..3309992)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (3270767..3280510)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37812 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37813 Neighboring gene predicted gene, 30057 Neighboring gene coiled-coil domain containing 152 Neighboring gene predicted gene, 41254 Neighboring gene growth hormone receptor Neighboring gene Ghr downstream L1 promoter region Neighboring gene Ghr upstream L2 promoter region Neighboring gene predicted gene, 22031

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables selenium binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    selenoprotein P
    Names
    plasma selenoprotein P
    seP
    selenoprotein P, plasma, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042613.2NP_001036078.1  selenoprotein P precursor

      See identical proteins and their annotated locations for NP_001036078.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Variant Sepp1b is specifically localized to the hippocampus in the brain, and is a specific target for regulation by miR-7 microRNA (PMID:23064117).
      Source sequence(s)
      AA153204, AK002450, CK627189
      Consensus CDS
      CCDS27357.1
      UniProtKB/Swiss-Prot
      P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
      Related
      ENSMUSP00000081004.6, ENSMUST00000082424.12
      Conserved Domains (2) summary
      pfam04592
      Location:23241
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:256380
      SelP_C; Selenoprotein P, C terminal region
    2. NM_001042614.2NP_001036079.1  selenoprotein P precursor

      See identical proteins and their annotated locations for NP_001036079.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Sepp1c) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
      Source sequence(s)
      AA153204, AI892015, AK002450
      Consensus CDS
      CCDS27357.1
      UniProtKB/Swiss-Prot
      P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
      Conserved Domains (2) summary
      pfam04592
      Location:23241
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:256380
      SelP_C; Selenoprotein P, C terminal region
    3. NM_009155.4NP_033181.3  selenoprotein P precursor

      See identical proteins and their annotated locations for NP_033181.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
      Source sequence(s)
      AA153204, AK002450, CB231357
      Consensus CDS
      CCDS27357.1
      UniProtKB/Swiss-Prot
      P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
      Related
      ENSMUSP00000124305.3, ENSMUST00000159216.10
      Conserved Domains (2) summary
      pfam04592
      Location:23241
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:256380
      SelP_C; Selenoprotein P, C terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      3300249..3309992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)