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    Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 105787, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkaa1provided by MGI
    Official Full Name
    protein kinase, AMP-activated, alpha 1 catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:2145955
    See related
    Ensembl:ENSMUSG00000050697 AllianceGenome:MGI:2145955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AMPKalpha1; C130083N04Rik
    Summary
    Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of gene expression; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; positive regulation of skeletal muscle tissue development; and regulation of peptidyl-serine phosphorylation. Located in several cellular components, including chromatin; dendrite; and neuronal cell body. Is expressed in several structures, including brain; dorsal root ganglion; early conceptus; liver; and spinal cord. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.3), limb E14.5 (RPKM 5.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prkaa1 in Genome Data Viewer
    Location:
    15 A1; 15 1.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5172641..5211380)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5143861..5181899)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene predicted gene, 41256 Neighboring gene STARR-seq mESC enhancer starr_37844 Neighboring gene predicted gene 15938 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2436 Neighboring gene prostaglandin E receptor 4 (subtype EP4)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables AMP-activated protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CAMKK-AMPK signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cold acclimation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cold acclimation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in energy homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid droplet disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect lipid droplet disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in motor behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tubulin deacetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell mediated immune response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adipose tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-lysine acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stress granule assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleotide-activated protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Names
    ACACA kinase
    AMP-activated protein kinase, alpha 1 catalytic subunit
    AMPK subunit alpha-1
    HMGCR kinase
    acetyl-CoA carboxylase kinase
    hydroxymethylglutaryl-CoA reductase kinase
    tau-protein kinase PRKAA1
    NP_001013385.3
    NP_001342569.1
    XP_036014946.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013367.3NP_001013385.3  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

      See identical proteins and their annotated locations for NP_001013385.3

      Status: VALIDATED

      Source sequence(s)
      AC135079, AK081874, AK160612, BY134921, CB245934
      Consensus CDS
      CCDS49574.1
      UniProtKB/Swiss-Prot
      Q5EG47
      UniProtKB/TrEMBL
      Q3TUQ7
      Related
      ENSMUSP00000063166.9, ENSMUST00000051186.9
      Conserved Domains (4) summary
      cd12199
      Location:404557
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:27279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:296360
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cd14079
      Location:24279
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    2. NM_001355640.1NP_001342569.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC135079
      Conserved Domains (3) summary
      cd12199
      Location:260413
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      cd14403
      Location:152216
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cl21453
      Location:1135
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5172641..5211380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159053.1XP_036014946.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      Q3TUQ7
      Conserved Domains (3) summary
      cd12199
      Location:434587
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      cd14403
      Location:326390
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cd14079
      Location:24309
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase