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    Ptger4 prostaglandin E receptor 4 (subtype EP4) [ Mus musculus (house mouse) ]

    Gene ID: 19219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptger4provided by MGI
    Official Full Name
    prostaglandin E receptor 4 (subtype EP4)provided by MGI
    Primary source
    MGI:MGI:104311
    See related
    Ensembl:ENSMUSG00000039942 AllianceGenome:MGI:104311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP4; Ptgerep4
    Summary
    Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; cellular response to mechanical stimulus; and regulation of cytokine production. Acts upstream of or within several processes, including regulation of ossification; response to lipopolysaccharide; and response to nematode. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; heart valve; and skin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 27.1), colon adult (RPKM 22.4) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptger4 in Genome Data Viewer
    Location:
    15 A1; 15 1.99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5262880..5273668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5233399..5244187, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, alpha 1 catalytic subunit Neighboring gene predicted gene 15938 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2436 Neighboring gene STARR-seq mESC enhancer starr_37846 Neighboring gene predicted gene, 41257 Neighboring gene ribosomal protein L22 like 1 pseudogene Neighboring gene beta galactoside alpha 2,6 sialyltransferase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin E receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin E receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables prostaglandin E receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T-helper cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to prostaglandin E stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ductus arteriosus closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within interleukin-33 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ductus arteriosus closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of eosinophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of eosinophil extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of integrin activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-1 alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of small intestine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcitonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of matrix metallopeptidase secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substance P secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substance P secretion, neurotransmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian sleep/wake cycle, wakefulness ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to nematode IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to prostaglandin E IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    PGE2 receptor EP4 subtype
    prostanoid EP4 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136079.2NP_001129551.1  prostaglandin E2 receptor EP4 subtype isoform 1

      See identical proteins and their annotated locations for NP_001129551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AC135079
      Consensus CDS
      CCDS49575.1
      UniProtKB/TrEMBL
      Q3UM94, Q91VE4
      Related
      ENSMUSP00000112858.2, ENSMUST00000120563.2
      Conserved Domains (2) summary
      pfam00001
      Location:34332
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29229
      7tm_4; Olfactory receptor
    2. NM_008965.2NP_032991.1  prostaglandin E2 receptor EP4 subtype isoform 2

      See identical proteins and their annotated locations for NP_032991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AC135079
      Consensus CDS
      CCDS27365.1
      UniProtKB/Swiss-Prot
      P32240
      UniProtKB/TrEMBL
      Q3UM94
      Related
      ENSMUSP00000048736.9, ENSMUST00000047379.15
      Conserved Domains (2) summary
      pfam00001
      Location:59357
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:54254
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5262880..5273668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)