klkb1.L kallikrein B1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: klkb1.L
Official Full Name: kallikrein B1 L homeolog
Primary source: Xenbase:XB-GENE-985054
Locus tag: XELAEV_18005339mg
See related: EnsemblRapid:ENSXLAG00005005716 AllianceGenome:Xenbase:XB-GENE-985054
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: klkb1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (46138136..46164725, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (36897982..36923901, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasma kallikrein B1

Names: kallikrein B, plasma (Fletcher factor) 1

NP_001086768.1

EC 3.4.21.34

XP_041436868.1

EC 3.4.21.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093299.1 → NP_001086768.1 plasma kallikrein B1 precursor

See identical proteins and their annotated locations for NP_001086768.1

Status: PROVISIONAL

Source sequence(s)

BC077417

UniProtKB/TrEMBL

A0A974I2J2, Q6AZS7

Related

ENSXLAP00005017017.1, ENSXLAT00005017313.1

Conserved Domains (3) summary

smart00223
Location:21 → 103

APPLE; APPLE domain

smart00020
Location:390 → 623

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:391 → 626

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

46138136..46164725 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041580934.1 → XP_041436868.1 plasma kallikrein B1 isoform X1

UniProtKB/TrEMBL

A0A8J1M5A3

Related

ENSXLAP00005017021.1, ENSXLAT00005017316.1

Conserved Domains (2) summary

smart00223
Location:21 → 103

APPLE; APPLE domain

cd00190
Location:391 → 626

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...