app.L amyloid beta precursor protein L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: app.L
Official Full Name: amyloid beta precursor protein L homeolog
Primary source: Xenbase:XB-GENE-479158
Locus tag: XELAEV_18011533mg
See related: EnsemblRapid:ENSXLAG00005024690 AllianceGenome:Xenbase:XB-GENE-479158
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: app
Summary: Predicted to enable DNA binding activity. Predicted to act upstream of or within several processes, including intracellular copper ion homeostasis; neuron development; and visual learning. Predicted to be located in Golgi apparatus; axon; and membrane. Is expressed in genital system; musculoskeletal system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (17761661..17906707)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (17563320..17709041)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.
Title: Biosynthesis and differential processing of two pools of amyloid-beta precursor protein in a physiologically inducible neuroendocrine cell.
A "CAGA" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.
Title: Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
endogenous cleavages at prohormone convertase-like sites in APP
Title: Endogenous C-terminal fragments of beta-amyloid precursor protein from Xenopus laevis skin exudate.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axo-dendritic transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axon midline choice point recognition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within collateral sprouting in absence of injury	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendrite development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mating behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of synapse structure or activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within visual learning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amyloid beta precursor protein L homeolog

Names: amyloid beta (A4) precursor protein L homeolog; beta-amyloid precursor protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088629.1 → NP_001082098.1 amyloid beta precursor protein L homeolog precursor

See identical proteins and their annotated locations for NP_001082098.1

Status: PROVISIONAL

Source sequence(s)

BC070668

UniProtKB/TrEMBL

A0A974DLG0, Q6NRR1

Related

ENSXLAP00005074362.1, ENSXLAT00005075943.1

Conserved Domains (7) summary

smart00006
Location:23 → 187

A4_EXTRA; amyloid A4

pfam00014
Location:292 → 340

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:30 → 130

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:655 → 692

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:695 → 745

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:132 → 187

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:345 → 527

APP_E2; E2 domain of amyloid precursor protein