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    ephx2.L epoxide hydrolase 2, cytoplasmic L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 447032, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ephx2.L
    Official Full Name
    epoxide hydrolase 2, cytoplasmic L homeolog
    Primary source
    Xenbase:XB-GENE-947549
    Locus tag
    XELAEV_18028284mg
    See related
    EnsemblRapid:ENSXLAG00005023831 AllianceGenome:Xenbase:XB-GENE-947549
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    sEH; ephx2
    Summary
    Enables epoxide hydrolase activity. Predicted to act upstream of or within regulation of cell growth. Is expressed in sensory system; vestibuloauditory system; and visual system. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ephx2.L in Genome Data Viewer
    Location:
    chromosome: 5L
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (165454655..165503511)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (154431215..154480157)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic alpha 2 L homeolog Neighboring gene uncharacterized LOC100496183 L homeolog Neighboring gene L-gulonolactone oxidase L homeolog Neighboring gene uncharacterized LOC108716390

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of Xenopus soluble epoxide hydrolase. Purba ER, et al. Biochim Biophys Acta, 2014 Jul. PMID 24681163
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC82903

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in peroxisome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epoxide hydrolase 2, cytoplasmic L homeolog
    Names
    soluble epoxide hydrolase
    NP_001087143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093674.1 → NP_001087143.1  epoxide hydrolase 2, cytoplasmic L homeolog

      See identical proteins and their annotated locations for NP_001087143.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078066
      UniProtKB/TrEMBL
      A0A974CZC3, Q6DCH2
      Related
      ENSXLAP00005070617.1, ENSXLAT00005072157.1
      Conserved Domains (4) summary
      TIGR02247
      Location:5 → 220
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      pfam00561
      Location:260 → 537
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21460
      Location:51 → 209
      HAD_like; Haloacid Dehalogenase-like Hydrolases
      cl21494
      Location:242 → 361
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      165454655..165503511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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